15-05-2016, 08:35 PM
https://en.wikipedia.org/wiki/Genistein
"Several studies have shown that both ERs and PPARs influenced each other and therefore induce differential effects in a dose-dependent way. The final biological effects of genistein are determined by the balance among these pleiotrophic actions"
https://en.wikipedia.org/wiki/Peroxisome...d_receptor
"The function of PPARs is modified by the precise shape of their ligand-binding domain (see below) induced by ligand binding and by a number of coactivator and corepressor proteins, the presence of which can stimulate or inhibit receptor function, respectively"
so it seems that ER's are co dependent with PPARs or symbiotic. may need to do further research on PPAR's to upregulate ER's availability to phytoestrogens.
more research needed
"Several studies have shown that both ERs and PPARs influenced each other and therefore induce differential effects in a dose-dependent way. The final biological effects of genistein are determined by the balance among these pleiotrophic actions"
https://en.wikipedia.org/wiki/Peroxisome...d_receptor
"The function of PPARs is modified by the precise shape of their ligand-binding domain (see below) induced by ligand binding and by a number of coactivator and corepressor proteins, the presence of which can stimulate or inhibit receptor function, respectively"
so it seems that ER's are co dependent with PPARs or symbiotic. may need to do further research on PPAR's to upregulate ER's availability to phytoestrogens.
more research needed