14-05-2016, 05:41 AM
(14-05-2016, 04:58 AM)Lotus Wrote:(14-05-2016, 02:38 AM)VergeOfDiscovery Wrote: Keeping in mind it's also a weak phosphodiesterase type 5 inhibitor and mimics testosterone in rats.
Gym rats no doubt.
The key point here is promoting estrogen bio-synthesis (e.g. NBE), while including Icariin with NBE it promotes aromatase (CYP19A) in human ovarian cell line. Think past cAMP (second messenger mRNA signaling).
PED type 5 inhibitors inhibit the CYP 450 enzyme. From what I've researched (and personally believe) is when we inhibit the signaling of CYP 450 enzymes, it magnifies the amount of free circulating E2.
No comprende, senora ... This is 100% Greek to me.
I do not understand the language of CYP, cAMP, mRNA, PED, etc., etc., etc.
I'm just hoping there is a "General Concencous" on what products can give you a woody while taking PM.
Should I search labels for what products contain Icariin ?
To dumb it down even further, try "Brand X" might be more to my understanding.
Thanks, again.

