[Lotus]

Coconut oil inhibits 5 alpha reductase (type 1 and 2) some 80-90% in the liver

Reishi inhibits DHT 80% in the prostate

Linoleic acid (LA) is a polyunsaturated omega-6 fatty acid inhibits 5 AR somewhat less in the liver at 70%


95% of endogenous androgen is produced by the testis, the rest is made up by adrenals. Once within the prostate, testosterone is rapidly and irreversibly converted to dihydrotestosterone (DHT) by the enzyme 5AR. This leads to a five-fold higher concentration of DHT versus testosterone within the intracellular prostate, versus an eleven-fold higher concentration of testosterone within the circulation. DHT then binds to the androgen receptor within the cytosol, is actively transported into the nucleus, and serves as a transcription factor for prostatic gene expression and thus prostatic cellular function. The higher concentration of intracellular DHT, in addition to its higher affinity for the androgen receptor, support the importance of 5AR in normal and pathologic prostate physiology (Partin and Rodriguez 2002).

Considering the potential to block DHT and increase aromatase adding fatty acids makes sense, only don't forget a fitness plan.

Anti-androgenic activity of fatty acids.

In this study, we show that 5alpha-reductase derived from rat fresh liver was inhibited by certain aliphatic free fatty acids. The influences of chain length, unsaturation, oxidation, and esterification on the potency to inhibit 5alpha-reductase activity were studied. Among the fatty acids we tested, inhibitory saturated fatty acids had C12-C16 chains, and the presence of a C==C bond enhanced the inhibitory activity. Esterification and hydroxy compounds were totally inactive. Finally, we tested the prostate cancer cell proliferation effect of free fatty acids. In keeping with the results of the 5alpha-reductase assay, saturated fatty acids with a C12 chain (lauric acid) and unsaturated fatty acids (oleic acid and alpha-linolenic acid) showed a proliferation inhibitory effect on lymph-node carcinoma of the prostate (LNCaP) cells. At the same time, the testosterone-induced prostate-specific antigen (PSA) mRNA expression was down-regulated. These results suggested that fatty acids with 5alpha-reductase inhibitory activity block the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) and then inhibit the proliferation of prostate cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/19353546

Green Tea Epigallocatechin-Green tea (camellia)-Reduce's the conversion of free testosterone into DHT and also raises SHBG (sex-hormone-binding-globulin). Also is for breast cancer prevention, reduces visceral fat. 4 cups a day

Spearmint-anti-androgenic properties reduce the level of free testosterone in the blood, while leaving total testosterone and DHEAS unaffected.

The study below is on spearmint, no mention of reducing 5 alpha reductase.

http://endometabol.com/?page=article&article_id=3644