14-01-2016, 07:27 PM
(14-01-2016, 01:18 AM)Lotus Wrote: A useful strategy for NBE could be to indenify what substrates will/won't work for us. We always think hormone testing (yes useful) is the first line of progress or problem areas (deficiencies). Instead, I think (if finances permitted) a human genome test could map out (or eliminate) the drugs we can't use. Is cost analysis worth the investment compared to all the drama that comes from our lost time, money, sanity waiting for boobs to finally grow.
in the absence of such an endeavor (genome testing) this (below) is the next best thing, yes complicated, but didn't we just find out that MSM inhibits DHT and promotes aromatase by using this method below:
(05-01-2016, 12:10 AM)Lotus Wrote: This is a post (smart fella, this MarDok42) from a PCOS board:
Quote:In the last few days my pharmacist friend explained to me when you block testosterone with one herb it will only block its production from one or two gene pathways, and a lot of the pro-hormones (hormone precursors) will find another pathway to testosterone, but it does give it a little longer to possibly become an estrogen. So to have more effective herbs, block more pathways with different types of herbs. Here's what I got so far.
Below are the genes that are involved in testosterone syntheses, they are the ones that start with 'CYP'. I have begun to cross referenced them with known chemicals in herbs that are known to inhibit these genes. If you want to find a synergistic herbal combination you might want to find a few herbs with these chemicals or others in it to inhibit(block) the majority of this gene set.
This is by no means a comprehensive list because I only started this project a week ago in my free time. But I thought that there might be other science geeks out there that would like to poke around the gene websites too.
Genes Involved in Testosterone Syntheses with corsponding inhibitors.
CYP1A2(also makes an Estrogen).....,cimetidine (inhibits)
CYP1B1(also makes an Estrogen)
CYP2B1– apigenin,Curcumin
CYP2B6– apigenin,Curcumin,Kaempferol
CYP2A3- lignans, genistein, Kaempferol
CYP2C11(Men Only)
CYP3A4 - lignans, Kaempferol, genistein, Curcumin (cimetidine, inhibits), sesame seeds and oil. Piperine
CYP3A5 - lignans, Kaempferol, genistein, Curcumin
CYP3A9 -
CYP19A1 -
Some Herbs and the anti androgen chemicals in them.
apigenin(chamomille)
Quercetin (chamomille)
genistein(Soy)
Curcumin(Vanalla, Turmeric)
Kaempferol(Peony, Dill)
lignans (Flax)
steroidogenic enzymes represent targets for complete suppression of systemic and intratumoral androgen levels, an objective that is supported by the clinical efficacy of the CYP17 inhibitor abiraterone.
Remember, by identifying these enzymes it provides information of drug-drug interactions. What's also key is the fact that certain cancers can be identified by examining these ezymens with interactions.
Here's a new one called CYP2C8, which metabolizes fatty acids. another CYP17's , which CYP17A modifies estrogen metabolism.
CYP2C8- lignans-Quercetin, linoleic acid
CYP17 -lignans-green tea (inhibits DHT)
CYP17A modifies estrogen metabolism
When used in quantities typical for flavoring food, black pepper is not likely to affect the disposition of most medications. However, excessive use of black pepper or intake of dietary supplements formulated with P. nigrum or P. longum extracts may produce clinically significant interactions with drugs. This may be of particular concern when CYP3A and/or ABCB1 substrates are ingested concomitantly with piperine or piperamides in excess of 10 mg.
http://www.ncbi.nlm.nih.gov/pubmed?filters=&orig_db=PubMed&cmd=Search&term=134%2A%5Bvolume%5D%20AND%201948%5Bpage%5D%20AND%202004%5Bpdat%5D%20AND%20Lambert%20JD%5Bauth%5D