10-01-2016, 06:10 PM
(10-01-2016, 05:06 PM)iaboy Wrote:(10-01-2016, 12:01 AM)Lotus Wrote: I've done more digging on PM too, (nod to xxd, he'll know what I mean). For instance, I still have an issue with my eye from when I used BO, (pressure and excess tear duct flow) it messes with me vision, aye!. (Plays tricks on me, e.g. typing lol) anyways.......I find that PM induces expression of the enzyme CYP1B1, which is active in many tissues, including structures of the eye.
Pm induces the expression of the enzyme CYP1B1 (which is explained as follows)
The function of the CYP1B1 enzyme in the development of the eye is unclear, but it may play a role in forming structures at the front of the eye and may also be involved in a process that regulates the secretion of fluid inside the eye.
http://ghr.nlm.nih.gov/gene/CYP1B1
Quote:CYP1B1 was induced by deoxymiroestrol, in which the gene expressions were time- and concentration-dependent patterns compared to those of estradiol.
Now, I also see this as an explanation of the optic migraines (jannet and others), which lead to glaucoma. Hint, I believe this has already been seen in a few cases here.
miroestrol and deoxymiroestrol might affect hepatic P450 enzymes, including the CYP2B9 and CYP1A2 P450 isoforms. More on this upcoming: it'll surprise you (about PM)
So, if I catch or boil down the $15 words, your suggesting that PM would or could cause irreparable damage to eyes???? So then, we are screwed either way we go... Pharma E can cause cancer's, DVT and promote other nasty's ..
I'm saying you'd better note any changes to ones health on PM, it has the potential just like estradiol would have in the eye. (Misty, myself, jannet, others too have had issues with our eyes).
Quote:It is not well understood how defects in the CYP1B1 enzyme cause signs and symptoms of glaucoma. Recent studies suggest that the defects may interfere with the early development of the trabecular meshwork, which is a network of mesh-like canals that helps drain excess fluid from the eye. If fluid cannot be drained, pressure inside the eye may increase, which is characteristic of glaucoma.