[Lotus]

Here's my attempt to tie this into a nice little bow.

Think about it, if we start attacking androgens pathway in the beginning we nearly euthanize DHT's chance to synthesize down stream. in essence we create a larger pool of free estrogen...... Sooo.....our goal is to find more non steroidal CYP inhibitors:

For those of us on Hrt we'd start this dissuasion with our Physicians about androgen deprecation therapy aka ADT. Although, I'd expect some rejection because it's less understood. Look, it's a novel (newer) way of chemical castration. And, if there's a way to eliminate or reduce (drugs we use) the potential harmful side effects (e.g. DVT, cancers) i think it's a smart move.