25-10-2015, 11:05 PM
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Follow along please:
Concentrations of aromatase and estradiol in the prostate are low, indicating that estradiol may not be the only estrogenic molecule to play a role in the prostate. It is known that DHT can be metabolized to 5alpha androstane-3beta,17beta-diol (3beta-diol), a hormone that binds to ERbeta but not to AR. The concentration of 3beta-diol in prostate is much higher than that of estradiol. Based on the high concentration of 3beta-diol and since this metabolite is a physiological ERbeta ligand, we hypothesized that 3beta-diol would be involved in the regulation of ERbeta expression.
Bottom line: there is solution to "this", (the potential breakthrough), I think somebody else can (should) provide the technology or key (besides myself). We shouldn't accept things at face value, never give up because someone suggests it's too difficult, or thst the answers don't exist.
Follow along please:
Concentrations of aromatase and estradiol in the prostate are low, indicating that estradiol may not be the only estrogenic molecule to play a role in the prostate. It is known that DHT can be metabolized to 5alpha androstane-3beta,17beta-diol (3beta-diol), a hormone that binds to ERbeta but not to AR. The concentration of 3beta-diol in prostate is much higher than that of estradiol. Based on the high concentration of 3beta-diol and since this metabolite is a physiological ERbeta ligand, we hypothesized that 3beta-diol would be involved in the regulation of ERbeta expression.
Bottom line: there is solution to "this", (the potential breakthrough), I think somebody else can (should) provide the technology or key (besides myself). We shouldn't accept things at face value, never give up because someone suggests it's too difficult, or thst the answers don't exist.