02-10-2015, 08:01 AM
Yeah that's a tough one, I believe Quercetin is bio-directional, meaning it could go either way. In that study it shows 2-3 fold activity in breast cancer test cells. cAMP (a second messenger) is also stated to an almost equal value as Quercetin, maybe slightly higher. Quercetin can raise SHBG, and when SHBG is high, aromatase will be down regulated. Imo, in lower concentrations (Quercetin) might work better, but everybody reacts differently, so results may vary.
Second messengers are molecules that relay signals received at receptors on the cell surface — such as the arrival of protein hormones, growth factors, etc. — to target molecules in the cytosol and/or nucleus.
But in addition to their job as relay molecules, second messengers serve to greatly amplify the strength of the signal. Binding of a ligand to a single receptor at the cell surface may end up causing massive changes in the biochemical activities within the cell.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html
To your question, is Quecertin useful for NBE, at this point I'd be more inclined to say forskolin would be better, but sourcing a legitimate product is the issue imo. Believe it or not you should look into horny goat weed, ICARIIN in goat weed is very much a second messenger, and it's about where (little below) the effectiveness as forskloin in an pro-aromatase. Vitamin D3 would also work too, (see previous posts regarding each in the thread).
Great question, thanks.
Second messengers are molecules that relay signals received at receptors on the cell surface — such as the arrival of protein hormones, growth factors, etc. — to target molecules in the cytosol and/or nucleus.
But in addition to their job as relay molecules, second messengers serve to greatly amplify the strength of the signal. Binding of a ligand to a single receptor at the cell surface may end up causing massive changes in the biochemical activities within the cell.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html
To your question, is Quecertin useful for NBE, at this point I'd be more inclined to say forskolin would be better, but sourcing a legitimate product is the issue imo. Believe it or not you should look into horny goat weed, ICARIIN in goat weed is very much a second messenger, and it's about where (little below) the effectiveness as forskloin in an pro-aromatase. Vitamin D3 would also work too, (see previous posts regarding each in the thread).
Great question, thanks.