19-09-2015, 03:04 AM
I have a theory (or an idea) 
on surge T levels caused by the increase in LH (lutenizing hormone). Chemical castration of serum testosterone is @ ≤50 ng/dL, thats between 93% and 99% elimantion. FSH (follicle stimulating hormone) up-regulates aromatase in both men and women. For this thoery its specific to the guys for the moment (sorry ladies).
Using this criteria (illustration and E2 study) below as an example, I think we can theorize that LH supresses GnRH release, which therefore blocks out FSH singaling too. That's where I think a critical error occurs, in other words, the synthesis of aromatase is missed. Hopefully I didn't lose yah yet,
any guesses what's the next move?, hint------it could be herbal or pharma, (one other clue) think surge (cascade).
17beta-estradiol.
Burnier AM, Martin PL, Yen SS, Brooks P.
Abstract
The sublingual absorption rates, the sustained effects, te biologic activity, and the metabolism of micronized 17beta-estradiol (E2) were measured in 10 postmenopausal women. E2 (0.5 mg) was administered in a single sublingual dose to five of the patients. An alternate-day schedule with the same dosage was used for the other five patients. In the single-dose study, a twenty-six fold increase in serum E2 and a ninefold increase in serum estrone (E1) concentrations were observed 1 hour after the sublingual deposition of E2 (0.5 mg). Serum concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were significantly decreased within 6 hours. The rise in E2 was early and peaked in the first 2 hours. The rise in E1 was slower and progressive, reaching its maximum thirteenfold increase at 4 hours, and remained two and one half times the baseline of 29 pg/ml at 24 hours, whereas E2 returned to the baseline level of 24 pg/ml. When micronized E2 was given in a dosage of 0.5 mg sublingually every other night, increased circulating levels of estrogens continued to be elevated at a minimum two and one-half fold baseline level for the week of study.
Mean levels (CMax) after 1 hour in this study were 773.6 pg/ml. Estrace 1 mg, cut in half (0.5 mg).
http://www.ncbi.nlm.nih.gov/pubmed/6786097
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![[Image: attachment.php?aid=9789]](http://www.breastnexus.com/attachment.php?aid=9789)
on surge T levels caused by the increase in LH (lutenizing hormone). Chemical castration of serum testosterone is @ ≤50 ng/dL, thats between 93% and 99% elimantion. FSH (follicle stimulating hormone) up-regulates aromatase in both men and women. For this thoery its specific to the guys for the moment (sorry ladies). Using this criteria (illustration and E2 study) below as an example, I think we can theorize that LH supresses GnRH release, which therefore blocks out FSH singaling too. That's where I think a critical error occurs, in other words, the synthesis of aromatase is missed. Hopefully I didn't lose yah yet,
any guesses what's the next move?, hint------it could be herbal or pharma, (one other clue) think surge (cascade).17beta-estradiol.
Burnier AM, Martin PL, Yen SS, Brooks P.
Abstract
The sublingual absorption rates, the sustained effects, te biologic activity, and the metabolism of micronized 17beta-estradiol (E2) were measured in 10 postmenopausal women. E2 (0.5 mg) was administered in a single sublingual dose to five of the patients. An alternate-day schedule with the same dosage was used for the other five patients. In the single-dose study, a twenty-six fold increase in serum E2 and a ninefold increase in serum estrone (E1) concentrations were observed 1 hour after the sublingual deposition of E2 (0.5 mg). Serum concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were significantly decreased within 6 hours. The rise in E2 was early and peaked in the first 2 hours. The rise in E1 was slower and progressive, reaching its maximum thirteenfold increase at 4 hours, and remained two and one half times the baseline of 29 pg/ml at 24 hours, whereas E2 returned to the baseline level of 24 pg/ml. When micronized E2 was given in a dosage of 0.5 mg sublingually every other night, increased circulating levels of estrogens continued to be elevated at a minimum two and one-half fold baseline level for the week of study.
Mean levels (CMax) after 1 hour in this study were 773.6 pg/ml. Estrace 1 mg, cut in half (0.5 mg).
http://www.ncbi.nlm.nih.gov/pubmed/6786097
[/quote]