[Lotus]

3. According to this site: http://www.poliquingroup.com/articlesmultimedia/articles/article/801/10_ways_to_lower_estrogen_toxic_load_.aspx @ 6) "Improve Estrogen Metabolism By Promoting the C-2 Pathway" it says that
"The C-2 pathway produces very weak estrogenic activity and is termed “good” estrogen. In contrast, the C-16 pathway produces robust estrogenic activity and promotes tissue damage that leads to cancer.

Key nutrients for supporting the C-2 pathway are EPA fish oils, phytoestrogens, and of special importance, B vitamins and a substance called DIM. The B vitamins, particularly B6, B12, and folic acid promote the C-2 pathway.

This is true, exercise, hydration and reducing stress and inflammation are absolutes too.

DIM is Diindolylmethane. It is an anticarcinogen and also improves estrogen metabolism. Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells* DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, although the atomic compositions of the two substances are quite different. Taken together with our published reports of the estrogen agonist activities of DIM, the present results establish DIM as a unique bifunctional hormone disrupter. To our knowledge, DIM is the first example of a pure androgen receptor antagonist from plants.
http://www.jbc.org/content/278/23/21136.full

B6 is also known to decrease gene activity once estrogen is bound to a receptor, meaning this vitamin can inhibit cell damage and cancer development."

Please point this out in related research. Reducing xenoestrogens from our daily life can prevent cell damage, go organic, stop using plastic (yeah, right lol).

so if i guess correctly promoting the C-2 pathway for a transsexual like me might be contra-productive. On the other hand i'm taking my estrogens sublingually, so most of it should go directly to the bloodstream and not through the metabolization pathway, so i don't have to cut down my vitamin intake, correct?
Vitamin B6 on the other hand sounds awful, but 1,4mg usually shouldn't matter against the pure quantity of 4mg estradiol.
Am i overseeing something?

I think you're missing progesterone. Don't go with synthetic progestin, instead choose bio-identical paraben free progesterone.

I'm again sorry to intrude, but i've been lurking this forum for about 3 years now and you're the person with the most knowledge about the endocrine system and alternative feminization regimes (non-synthetic) i know of. ^.^;

kind regards
Anna

I dunno bout that, , we have plenty of people who know what's up, I just post a lot.


If your gonna do DIY lets talk about it, granted, we all know it's not the recommended way, everybody condones it, you assume the risk. Hopefully you know about the dangers of buying overseas meds and the health risks involved. Ok then..........

Sublingual delivery reduces the risk of hepatic injury, DVT and other vascular conditions, (doesn't eliminate mind you).

Risk factors for venous and arterial thrombosis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096855/pdf/blt-09-120.pdf


* 4mg Estradiol Hemihydrate (sublingually; 2mg mornings, 2mg evening)

The binding rate of E2 isn't as strong as people think, but sublingual E2 inside of an hour has a 26 fold increase and 9 fold increase of E1. It's also noted that E2 continued to circulate 2.5 fold during the week of the trail, suggesting that E2 will still be active for at least a week..

Sublingual absorption of micronized 17beta-estradiol

Abstract
The sublingual absorption rates, the sustained effects, te biologic activity, and the metabolism of micronized 17beta-estradiol (E2) were measured in 10 postmenopausal women. E2 (0.5 mg) was administered in a single sublingual dose to five of the patients. An alternate-day schedule with the same dosage was used for the other five patients. In the single-dose study, a twenty-six fold increase in serum E2 and a ninefold increase in serum estrone (E1) concentrations were observed 1 hour after the sublingual deposition of E2 (0.5 mg). Serum concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were significantly decreased within 6 hours. The rise in E2 was early and peaked in the first 2 hours. The rise in E1 was slower and progressive, reaching its maximum thirteenfold increase at 4 hours, and remained two and one half times the baseline of 29 pg/ml at 24 hours, whereas E2 returned to the baseline level of 24 pg/ml. When micronized E2 was given in a dosage of 0.5 mg sublingually every other night, increased circulating levels of estrogens continued to be elevated at a minimum two and one-half fold baseline level for the week of study.
PMID 6786097 [PubMed - indexed for MEDLINE]

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* 5mg Finasteride (Proscar) (1x mornings; on empty stomach)

I'd split Finasteride into two doses, Finasteride's half life is about 4-5 hours.

Finasteride modestly increases serum testosterone (T), estrone (E1), and estradiol (E2). Aka-it increases libido, acne, and oily skin, just FYI, or be on the look out, lol. I have Finasteride as a slight aromatase modifier, 22%.

finasteride blocks the conversion of testosterone to dihydrotestosterone (DHT) and of androstenedione to 5α-androstanedione-3,17-dione, which also leads to the reduction of DHT.

I'll pick this up tomorrow, phew, that was a big list though, I'm still not done yet, I'm tired. have a good night.