[Lotus]

Hi Lotus,

sorry to intrude your thread. I hope you don't mind that i wanted to ask you three things.

Hi Railgun, (either your ex-military type or you like blowing stuff up for the helluva it, lol),

Let me first just say this, (my own personal opinion), there's a medium ground between NBE/HrT, and some may say it's a cardinal sin to cross the proverbial boundaries, in my mind, not so anymore. Honestly, it's splitting hairs, I've seen enough and posted enough research (check it all) to see both sides of the pros/cons. What both sides miss is not more ER stimulation, but more gene expression. Look, you can stimulate estrogen receptors all day long and still not gain an advantage. In other words, some E2 will make it past the cell membrane surface into the cytoplasm and "not" move into the nucleus for nuclear binding, it's either not the right fit or its degraded, protein expression is lost. For instance, some Xenoestrogens bind to receptors are cause damage (cancers, over expression, aka-estro dominance). Improving the bioavailability of both is a good strategy. I've reported that EFA's are a carrier protein, in particular palmitate (also in skin application, estrogen receptors are favorable using a carrier, [palmitoleic]). Sorry if this gets technical here, intracellular cAMP production and the promoter-specific expression of mRNA coding for CYP19 equals aromatase, aka-gene expression.

That's part of what limits both productions, plus we don't include enough E1/E2 in the presence of progesterone. You will find it rare that anyone suggests the dual expression on a regular basis, oh sure progestin is prescribed with HrT, IMO it has to be bio-identical, and some Hrt programs already have it. However, it should be applied to the breasts, e.g. applying PM or E2 gel w/paraben free bio-identical PC, I'd even go a step further and say add coconut oil to this procedure.

One other thing I see as a possibility is forcing DHT into ER-b, in other words deactivate DHT. I think I shared that discussion (hypothesis) on the anti-androgen page. Also, nitric oxide synthase modulates lipolysis in adipocyte (builds breast tissue).

I've hijacked my own thread, sorry Railgun, I do have some suggestions on herbs for Hrt, I'll get to it in a minute, RL is calling.