[Lotus]

So, what does this mean in layman's terms, Lotus? I don't understand a word of that! And does it mean we don't need to bother with white peony (or was it reishi?!)

No no, don't stop WP.

It just means that we have another tool in the tool shed for NBE, or in other words the prostrate and male reproductive organs has more estrogenic pathways (& production) than previously thought. I'm just in the process of connecting the dots and how these metabolites can help us. (Some theorized other metabolites had no value and dismissed them, here we clearly this that's not the case).


This next paragraph explains the process and is a step in the right direction.


Concentrations of aromatase and estradiol in the prostate are low, indicating that estradiol may not be the only estrogenic molecule to play a role in the prostate. It is known that DHT can be metabolized to 5alpha-androstane-3beta,17beta-diol (3beta-diol), a hormone that binds to ERbeta but not to AR. The concentration of 3beta-diol in prostate is much higher than that of estradiol. Based on the high concentration of 3beta-diol and since this metabolite is a physiological ERbeta ligand, we hypothesized that 3beta-diol would be involved in the regulation of ERbeta expression.

And this might help too.



   

An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth.
http://www.ncbi.nlm.nih.gov/pubmed/12370428