[Lotus]

♦ Studies demonstrate that ERβ-mediated estradiol actions are vital to FSH-induced granulosa cell differentiation.

♦ Protein interaction between ER alpha and ER beta was demonstrated in vitro by GST pull-down assay and in vivo by immunoprecipitation. Thus, this study indicates that ER alpha and ER beta can interact in vivo, cross-signaling each other.

♦ Studies on large doses of fenugreek on four target organs—the liver, stomach, kidney and small and large intestine—reveal that the liver is the only one affected by the high doses. (Although anything in high doses isn't a good idea to begin with, why take the risk).

Animal research on fenugreek toxicity reveals that very large doses of the herb can lead to mild hepatitis according to Aziza M. Hassan, lead author of a study published in the "African Journal of Biotechnology."


   

Clinical Studies on Fenugreek.
http://www.arthmender.com/clinical_studies/fenugreek

Fenugreek Benefits for Men
http://www.livestrong.com/article/513411...s-for-men/

Libido enhancement supplements produced from fenugreek claim to increase sexual desire and performance in men. In a study published in the February 2011 issue of “Phytotherapy Research,” researchers recruited 60 men between the ages of 25 and 52 years without a history of erectile dysfunction and supplemented them with either a placebo or 600 milligrams of fenugreek extract per day for six weeks. The participants self-evaluated their satisfaction with fenugreek and reported that the supplement had a positive effect on libido. The study found that fenugreek extract had a significant influence on sexual arousal, energy and stamina and helped participants maintain a normal testosterone level.




♦ If estradiol is around in high enough dosages, it can bind to progesterone receptors and androgen (male hormone) receptors as well as to estrogen receptors