[Lotus]

Wow.Lotus.Thank you,you can help me very much.You have better and better idea.androgen blocker/estrogenic too this is great!

What is that aromatase?


There's an enzyme in the bodies of both men and women called aromatase. Its primary action is to produce female sex hormones, or estrogens. It produces them from male sex hormones (androgens) such as testosterone and their precursors.
Aromatase also converts androstenedione (a sex hormone precursor) to the female hormone estrone, another estrogen, although weaker than estradiol.
If you increase the activity of aromatase, you can increase levels of female sex hormones (estradiol, estrone).

What it means: blocks 5-ar?

5-ar - 5 alpha reductase - the enzyme that converts testosterone into dht. (It's like the aromatase enzyme). This is the one we want to prevent.

Inhibition of 5α-reductase results in decreased conversion of testosterone to DHT, leading to increased testosterone and estradiol. Other enzymes compensate to a degree for the absent conversion, spec voifically with local expression at the skin of reductive 17b-hydroxysteroid dehydrogenase, oxidative 3a-hydroxysteroid dehydrogenase, and 3b-hydroxysteroid dehydrogenase enzymes. Inhibition of the enzyme can be classified into two categories: steroidal, which are irreversible, and nonsteroidal. 5-α reductase 2 is the one we're interested in, there's more but it gets extremely complicated so I'll spare you the gory details.

Herbs that help block 5 ar, licorice, WP, Reishi, SP, pygeum, nettle root, BO (not an herb), Chinese Skullcap, progesterone cream is a strong 5 ar, linolenic acid, green tea.


5α-reductases catalyze the following chemical reaction:
a 3-oxo-5α-steroid + acceptor a 3-oxo-Δ4-steroid + reduced acceptor
http://wikipedia.org/wiki/5-alpha_reductase

is extract more effective than capsules?

Generally yes imo, the first pass of Metabolism is greatly reduced, (not eliminated) but releases directly into the bloodstream.


First pass metabolism is what occurs when a drug is absorbed from the GI tract. When a drug is taken orally it is absorbed into the portal circulation (the blood vessels of the liver). Many of these drugs are very efficiently metabolized (altered for elimination) as they pass through the portal circulation during this first time. It reduces the amount of active drug that gets into the general circulation. This is first-pass metabolism.

Well i have a little confusion.
I take PM 1000 mg now,I'll be careful LC 250 mg /third days
And what is the white peony right dose with these together?

WP- 2-3x of the dropper mixed with water (6-8oz seems ok)

This is the rank: one day PM/another day LC and White Peony?

WP-I would say every other to start then combine (all) in the second week.


furthermore: does not Maca work against estrogenic?

It's said to balance the hormones, (helps control E-dominance)