01-04-2015, 09:12 PM
(01-04-2015, 06:30 AM)Lotus Wrote:(31-03-2015, 10:10 PM)-Clelia- Wrote: "What's also interesting is how upon excertion steroids are water soluble"-->Yes exactly, (for transport), ion channels are the access of cell diffusion correct?, assuming carrier proteins are the vehicles to mitochondria, what keeps the channels open long enough expression?, I see its from 1/100 hundredth to 1/1000 thousands of seconds, could this explain partial binding?.
mmh... why do you want to know that? for transport?
I think that there is no necessity of a ion channel for the access of steroids in the cell. They should simply cross the membranes by diffusion:
"After secretion by the endocrine glands, the hormones are transported to the target tissues via the blood, where their major fraction is bound to the serum proteins β-globulin and albumin. According to the genomic mechanism, the lipophilic character of the hormones enables them to dissociate spontaneously from the carriers and enter the target cell by transbilayer passive diffusion. Inside the cell, the hormones bind to intracellular receptors that shuttle between the nucleus and the cytoplasm in an inactive state (Lundberg, 1979). Binding to the hormones induces conformational changes and reorganization to active hormone-receptor complexes (Guiochon-Mantel et al., 1996). Subsequently, the complexes migrate to the nucleus, where they bind to hormone-responsive elements on the DNA and regulate synthesis of new proteins that are required for the hormone's action (Chen and Farese, 1999; Beato and Klug, 2000)."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304487/