[Lotus]

O.k., I am no scientist, but here is a wild thought. Could the membranes in female breast's be somewhat different than their brother's?? Maybe the xy combo chromosome double locks the male breast somehow?? Or at the least makes it less permeable to Estradol expression or straight out E in all forms?????

iaboy, I like Clelia's explaination, what's weird is that I tried to address/explain the exact cause (or, lack of cause) for why the breast growth response is individually diverse. And.....well.....you know me to go over board with info. but...here's my .02 cents worth.

hi, i think the main difference between male and female is in the AR receptor number in breast tissue. Also, hormones play another important role. What is fondamental to development are the ratios: AR/ER, androgen/estrogen. The higher are those numbers, the smaller is your breast

Out of interest, would they have been markedly different on an HRT regimen, do you think? (Not that I propose to follow one).

It's hard to say. What is interesting is when PM gets carried over to hrt from nbe. The two receptor proteins (alpha and beta) are well documented, the relationship between NBE, HRT, Breast Cancer is somewhat tied together, and explains how/why growth is mediated.

Role of receptor complexes in the extranuclear actions of estrogen receptor a in breast cancer
http://erc.endocrinology-journals.org/co...3.full.pdf


We've seen folks on hrt return to nbe, and then go back on hrt. Receptor mediated growth (or lack thereof) explains quite a bit. For instance (and this will sound crazy) you've heard the term "they have good genes, or the good genes passed on, etc etc, its quite possible and directly related to the amount of breast growth genes (per this example), imo it best describes the relationship between small breasted to large breasted women ( put men in this group too, since we have the same receptors).

I tend to look at how these proteins (enzymes) are structured, meaning what influences the binding process, e.g. protein kinase or the phosphorylation of proteins, PPK, TNF receptor family, cAMP, caveolin, with signaling proteins, G-proteins, Src-like kinases, I mean the list goes on and on.

Tap into signaling pathways (intracellular) or.... what inhibits cells migration ..... LBD (ligand binding domain) which is mediated somewhere @ 66% of ER-a domain and the doors start opening for breast growth......well....that's certainly my opinion. All the research is there, it's just interpreting into language humans can understand, easy right?.

Now Clelia is here to help interpret (lol, translate) right Clelia.