[Lotus]

lotus, you reported:
"Concentrations of aromatase and estradiol in the prostate are low, indicating that estradiol may not be the only estrogenic molecule to play a role in the prostate. It is known that DHT can be metabolized to 5alpha-androstane-3beta,17beta-diol (3beta-diol), a hormone that binds to ERbeta but not to AR. The concentration of 3beta-diol in prostate is much higher than that of estradiol. Based on the high concentration of 3beta-diol and since this metabolite is a physiological ERbeta ligand, we hypothesized that 3beta-diol would be involved in the regulation of ERbeta expression."

and that's fine, but... you know that this is not the case in male breast tissue, otherwise you should have breast growth like bio-female...
in men there is more androgenic expression than the estrogenic one. Maybe estradiol is not the only estrogen, but the DHT metabolite "3-b-diol" isn't enough to gain breast growth in biomale breast tissue.
I think that DHT is not converted to the "estrogen-like metabolite" in the breast, at least not in the same amount as it is in the prostate.

So that's why i think that is better low DHT for breast growth

Hi Clelia,

Thanks for the excellent info, now this is telling........I do have a hypothesis of my own too.

I think that DHT is not converted to the "estrogen-like metabolite" in the breast, at least not in the same amount as it is in the prostate.

a hypothetical about DHT, (but first), for the longest time I thought DHT had no usable purpose in terms of breast growth. Now, we discover it has a back door useable metabolite in the prostate and Sertoli cells. So....then, is it yet to be discovered that DHT in breast tissue "can" in fact....have the usable ER-beta metabolite??.....that is my hypothetical, I see you think perhaps the same is true.

We've just opened a whole can of worms.......imo it's the gummi type (yum yum).

sorry about that :-/ i'm not mothertongue

No problem, Io capisco perfettamente,

Sorry, but I've have 4-5 research papers just related to our discussion that I'll share next.