[Lotus]

Hi Lotus, i like reading your posts, now I have no much time to answer, but I can tell you something

Thanks Clelia, , I appreciate your time.

Research is often controversial, because maybe in different studies there are differences that could affect results (for example, in vivo and in vitro can change final results).

Great point, I noticed limitations in some studies (e.g. available test samples w/regards to country's ban or limitations) could affect results, but I understand what you mean.

Also, we should take account of the target of the subject: different tissues can respond in different ways, with same inizial conditions. This is due to the variability of the receptor expressed in every tissue, which often are not the same and in same amount (understandably).

Ok, Like multiple response, or unintended consequence.

So, your research about the "estrogen DHT metabolite", is based on prostate, not breast tissue or skin. That's why men become bald: there is androgen dominance in their skin, and fighting DHT is proved good to grow hair.
Also, the DHT metabolite, interacts with ERb, and we know that alfa is better for breast growth, isnt it?

BPH/prostate research does seemed skewed towards 5-ar inhibitors/ anti DHT. Since the prostate is pro ER-a it seems likely estrogen could be a mediator of cancers too.

Its good to try to convert DHT in estrogen metabolite, but i think its better to shut it down, at least for breast growth.

I've seen some promising research that includes androgen blockade therapy, 17beta -HSD, even using prolactin molecules to box out DHT because of their larger size, suggesting to me PRL is DHT inhibitor. But I think COX is also an aromatase at PGE.

And if you do this, what about your prostate risk? Since the metabolite help prevent prostate cancer, what if you low it? I think you should read this also, maybe there are other mechanisms involved, in prostate cancer:

Yes, elimaniting androgen/DHT ip even in Mtf has long term consequence. The biological affects of androgens are are still needed. The assumptation of testosterone being poison is often misinterpreted. Testosterone is the sex hormone that converts to all estrogens, without T Mtf wouldn't make the necessary conversion to transition. I think it's a mistake to reduce testosterone, the reduction is needed at DHT...... and the reason is quite obvious.

" Anti-androgenic activity of fatty acids." www.ncbi.nlm.nih.gov/pubmed/19353546 (2009)

Great link, thank you so much, I can only think of two supplements that cam meet that demand........coconut oil and EPO-evening primrose oil.