[Lotus]

Thank you

And thanks about the interesting research linked (maybe would have been better if they added alpha linolenic acid on their omega 3 research, but our body should convert it to DHA and EPA).


What a nice coincidence, that research group is close where I live.
Usually i write on the italian forum, so i am here just to thank you and report links that i didnt find on your demanding thread (thanx i have a BSc degree... That helped me a lot ).
Your research is very good There is always a point where to start, then research brings you everywhere.

Btw, I have a question, what hormones a biomale should check, prior her program?

Thank you so much for that comment.....and wow a BSc degree (too cool)

Btw, I have a question, what hormones a biomale should check, prior her program?

This could be expensive......but I'd have these checked,
total (T), free (FT), bioavailable testosterone (bT), oestradiol (E2), bioavailable oestradiol (bE2), oestrone (E1), sex-hormone binding globulin (SHBG), and insulin-like growth factor 1 (IGF-1), also progesterone, DHEAS, cortisol. albumin.

Or if that doesn't work I'd do this:
FT, E2, Progesterone.......some sites offer package deals (e.g 5 tests), seems to be the most popular, that's around $100 to $150.00 (U.S.).


Ok......now I have a question for you. (I hope you don't mind).....I'm very interested in membrane fluidity (atm lol), anyways... what would you think if I said that the palmitoylation of estrogen receptor alpha (ER-a) is (or can be) mediated by oxidative phosphorylation?. Incidentally, I'm sure you're aware that fatty acids synthesize aromatase, (what are your thoughts?).

On another note....I've seen that EPA and DHA reduces the risk of breast cancer by as much as a 32% reduction, I don't know the dosage.

Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer.
Mobley JA1, Brueggemeier RW.
Author information
Abstract
Estrogens have been implicated to be complete carcinogens in breast and gynecologic tissues. Possible mechanisms may include differential metabolism with subsequent formation of reactive oxygen species and/or a receptor-mediated pathway, which may also involve indirect modulation of intracellular redox state. Estrogen-mediated oxidative DNA damage in mammary gland epithelia includes the induction of 8-oxo-2'-deoxyguanosine, both in vitro and in vivo, thereby suggesting a role for oxidative stress in the initiation and/or progression of breast neoplasia. In order to study this phenomenon, we have treated estrogen receptor alpha (ER-alpha)-positive MCF-7 cells and ER-alpha-negative MDA-MB-231 cells with 10 nM 17beta-estradiol (E2), while measuring changes in antioxidant status and sensitivity to DNA damage by peroxide. Treatment of MCF-7 cells with E2 resulted in a marked decrease in the ability for these cells to metabolize peroxide, which paralleled a decrease in catalase activity and total glutathione levels. These observations also correlated with an increased sensitivity to peroxide-induced DNA damage. The estrogen-induced effects were all opposed by the anti-estrogen tamoxifen. In addition, the estrogen-mediated down regulation of peroxide metabolism, catalase activity, and sensitivity to DNA damage were not observed in the MDA-MB-231 cell line. Treatment of MCF-7 cells with E2 also resulted in increased glutathione peroxidase, superoxide dismutases (I) and (II) and glucose-6-phosphate dehydrogenase activities. Therefore, in this breast cancer model antioxidant status is modulated through the actions of the ER. The data may explain some of the estrogen-induced pro-oxidant effects previously reported in vivo. In addition, this is the first report indicating that E2 is capable of inducing an increase in sensitivity to oxidative DNA damage through an ER-mediated mechanism.

ETF red + Q → ETF ox + QH2 (Sorry)

Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol.
http://www.ncbi.nlm.nih.gov/pubmed/15496458


Effects of Dietary Fish Oil Supplementation on the Phospholipid Composition and Fluidity of Cell Membranes from Human Volunteers
http://www.karger.com/Article/Abstract/12797
The full study is behind a pay wall (drat...)