[spanky]

ER-b (estrogen receptor beta) slows breast growth, which is great in preventing cancer, but if you have a phytoestrogens that have an affinity for this receptor it means very slow growth. PM has multiple phyto's that favor the ER-b type, this is why it takes longer. Dexy & miroestrol are definelly the stronger phyto's of PM (granted), they have an affinity for ER-a (growth receptor).

But still, daidzien in PM opposes E2 action, it acts like a phyto-androgen.

You'd want a phytoestrogen that favors the growth receptor alpha (ER-a) but not to aggressive. Vitex and RC look like they fit the task. Now you add in coconut oil, (which is for building tissue and blocking 5 ar, and aromatase). A strong plamitic acid needs to be sourced though (Palm oil ???? I dunno yet) something in the palm family. Saw Palmetto??, I'm still not sure about that one yet, it still down-regulates progesterone receptors, so still searching.

Buttttt, Estrogen receptor alpha is made up from palmitoylated protein, which is palmitic acid, this is why it's the holy grail.

ERa is a palmitoylated protein
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246083/

Meaning if you take a palm product before supplementing with something like vitex or RC the door (estrogen receptor alpha) is left open. Fatty acids like coconut oil, or anything in the omega 3-6-7-9 family will help with growth.

Make sense?,

Yes -- it does make sense. If one goes that route (rather than sticking with PM), do you have any recommendation for the dosage of Vitex or RC? How about coconut oil?

There are Vitex extracts, but they seem VERY expensive as opposed to capsules.

Also, I have seen warnings against combining Vitex with progesterone but do not know what the problem is. (http://www.ehow.com/way_5474914_vitex-br...rowth.html). Do you think that warning would apply even if you are cycling and stop vitex before applying progesterone cream?

I have seen discussion (not sure how authoritative) indicating that vitex boosts progesterone and reduces prolactin.

http://www.network54.com/Forum/371678/th...with+Vitex

As for palmitic acid, isn't it connected with increased risk of cardiovascular disease? I think the Wiki on palmitic acid indicates that the WHO says this is so.