It looks like those words are quoted from the link. Can you summarize important points of texts, next time.
See this thread, Serum Estriol and Estetrol and Estriol: Safety and Efficacy
Your post shown has the claim that estriol is 1000 times less potent on tissue than estradiol, then it says its 8% as strong. Wikipedia says, which is still unverified that estriol is 80 times less potent than estradiol. The two claims on potency are close, except the effects on tissue. An explanation for this could be how a hormone can respond weaker to one receptor or subtype while stronger to another. Estriol has less affinity for binding. Let's say estriol hardly binds to SHBG, and it is 1000 times less potent, and there is more of it in the blood stream, that already means estriol has a strong effect. even more so it it is 8% as strong as estriol.
The paper differs in that this one from '98 says, estriol has been prescribed, and the conflicting paper says they stopped prescribing it in the US. The body produces estriol, so a prescription isn't needed. I think its irrelevant if estriol doesn't convert into estradiol, the paper makes an assumption that estriol isn't very useful because of that.
Over 80% of estradiol is bound to SHBG. Your post claims that "about 95% or more of the blood level hormones are protein bound." It doesn't specify which hormone, but that doesn't conflict with the other statement.
Estriol is safer than estradiol, in terms of cancer. Estriol, and estradiol break down into other compounds, one of which may be a carcinogen. Estriol can also be eliminated through fiber in the intestines. I think Estriol coexists with progesterone and prolactin, all three which directly are useful for NBE. Also, since Estriol is high during pregnancy, there is no risk to the fetus from it, in fact the fetus produces estriol, from conversion from estradiol. The body produces estriol already, but a fetus does this to remove the estradiol that threatens it. Estrone is the most carcinogenic, and converting estrone to estriol is good.
Birth control pills are given with both estrogens and progestogens to reduce incidences of cancer. Perhaps it is best to increase both estrogens and progestogens together, and this takes care of a lot. As prolactin increases progestogens, these two lower estradiol. Perhaps this estradiol is converted into estriol. I'm theorizing this causes a triple effect from increasing prolactin to aid in progesterone and estriol production, which all three cause NBE.
See this thread, Serum Estriol and Estetrol and Estriol: Safety and Efficacy
Your post shown has the claim that estriol is 1000 times less potent on tissue than estradiol, then it says its 8% as strong. Wikipedia says, which is still unverified that estriol is 80 times less potent than estradiol. The two claims on potency are close, except the effects on tissue. An explanation for this could be how a hormone can respond weaker to one receptor or subtype while stronger to another. Estriol has less affinity for binding. Let's say estriol hardly binds to SHBG, and it is 1000 times less potent, and there is more of it in the blood stream, that already means estriol has a strong effect. even more so it it is 8% as strong as estriol.
The paper differs in that this one from '98 says, estriol has been prescribed, and the conflicting paper says they stopped prescribing it in the US. The body produces estriol, so a prescription isn't needed. I think its irrelevant if estriol doesn't convert into estradiol, the paper makes an assumption that estriol isn't very useful because of that.
Over 80% of estradiol is bound to SHBG. Your post claims that "about 95% or more of the blood level hormones are protein bound." It doesn't specify which hormone, but that doesn't conflict with the other statement.
Estriol is safer than estradiol, in terms of cancer. Estriol, and estradiol break down into other compounds, one of which may be a carcinogen. Estriol can also be eliminated through fiber in the intestines. I think Estriol coexists with progesterone and prolactin, all three which directly are useful for NBE. Also, since Estriol is high during pregnancy, there is no risk to the fetus from it, in fact the fetus produces estriol, from conversion from estradiol. The body produces estriol already, but a fetus does this to remove the estradiol that threatens it. Estrone is the most carcinogenic, and converting estrone to estriol is good.
Birth control pills are given with both estrogens and progestogens to reduce incidences of cancer. Perhaps it is best to increase both estrogens and progestogens together, and this takes care of a lot. As prolactin increases progestogens, these two lower estradiol. Perhaps this estradiol is converted into estriol. I'm theorizing this causes a triple effect from increasing prolactin to aid in progesterone and estriol production, which all three cause NBE.