20-09-2014, 10:35 PM
Chapter 10, the Breast, is very good. It has a lot of information that I was looking for, plus a little bit more, in one place. I'll add it to biology.
I don't think genetics should be messed with. What is proved, however, is the importance of aromatases. Anti-reductases, and plant based analogs are also imporant. 16a-OHase through liver conversion might also be important for forming estriol from other estrogens, which is safer and more bioavailable than estradiol.
https://www.ncbi.nlm.nih.gov/mesh/?term=16alpha-Hydroxylase Steroid 16-alpha-Hydroxylase (16a-OHase) This enzyme is shown in the above link 'Estriol: Safety and Efficacy' under Figure 1.Biosynthesis of estrogens. It shows the pathway from Dehydroepiandrosterone (DHEA), to Androstenedione, to testosterone, to estradiol, to estriol. The chart shows aromatases making conversions to estradiol, estrone, and estriol.
I wonder if blessed thistle which has a role in helping the liver, and is also a lactogogue has an effect in any way on an estrogen pathway.
On the other hand, estriol may not be normal for the body to synthesize in large amounts, so it may possibly be irrelevant. Estriol is synthesized by a small amount by the liver, and also by a large amount by a placenta.
I don't think genetics should be messed with. What is proved, however, is the importance of aromatases. Anti-reductases, and plant based analogs are also imporant. 16a-OHase through liver conversion might also be important for forming estriol from other estrogens, which is safer and more bioavailable than estradiol.
https://www.ncbi.nlm.nih.gov/mesh/?term=16alpha-Hydroxylase Steroid 16-alpha-Hydroxylase (16a-OHase) This enzyme is shown in the above link 'Estriol: Safety and Efficacy' under Figure 1.Biosynthesis of estrogens. It shows the pathway from Dehydroepiandrosterone (DHEA), to Androstenedione, to testosterone, to estradiol, to estriol. The chart shows aromatases making conversions to estradiol, estrone, and estriol.
I wonder if blessed thistle which has a role in helping the liver, and is also a lactogogue has an effect in any way on an estrogen pathway.
On the other hand, estriol may not be normal for the body to synthesize in large amounts, so it may possibly be irrelevant. Estriol is synthesized by a small amount by the liver, and also by a large amount by a placenta.