[Lotus]

Hi Annie,

As to my 'paste', it is just a convenient way to take those things I get in powder form, and my main concern was whether the close admixture of shatavari and maca with PM would reduce the effectiveness of the PM. In fact I am of course taking various other things in the morning including as well as the paste ramiprilHCT (ACE inhibitor + diuretic), warfarin, oxybutynin, horse chestnut, a multivitamin & mineral pill and a CoQ10, fish oil & vegetable sterol capsule. In the evening tamsulosin, diltiazem (calcium channel blocker),oxybutinin, PABA, the CoQ10 etc. capsule, and horse chestnut. For all the things that are supposed to be taken spaced apart there are not enough hours in the day!

Ultimately I wouldn't mix the PM, imo I wouldn't want it to lose potency along the way to E receptors because of an interaction making it less active. I have a list of supplements that when taken with certain meds will increase plasma concentrations. Meaning it will boost certain supplements, just as grapefruit juice does. I have reservations sharing the info openly for fear of somebody without experience harming themselves. I think WebMD and drugs.com has some of the best supplement interaction info out there. Peggy made a nice list here, http://www.breastnexus.com/showthread.php?tid=19869 I'm going to add to the list ASAP, btw I added Horse Chestnut to it though.

Grapefruit juice reduces warfarin effectiveness, so I'd skip the juice for now.

Shatavari- might act like a diuretic
http://www.webmd.com/vitamins-supplements/ingredientmono-1167-ASPARAGUS%20RACEMOSUS.aspx?activeIngredientId=1167&activeIngredientName=ASPARAGUS%20RACEMOSUS

Maca
http://www.webmd.com/vitamins-supplements/ingredientmono-555-MACA.aspx?activeIngredientId=555&activeIngredientName=MACA
http://www.drugs.com/npp/maca.html

Horse chestnut might act like a diuretic and might decrease blood sugar
http://www.webmd.com/vitamins-supplements/ingredientmono-1055-HORSE%20CHESTNUT.aspx?activeIngredientId=1055&activeIngredientName=HORSE%20CHESTNUT

oxybutynin-This medication may cause blurred vision and may impair your thinking or reactions.
http://www.drugs.com/oxybutynin.html

Dutasteride-a potent androgen, localized edema, serious skin reactions. Tamsulosin plasma concentrations may be elevated, increasing tamsulosin exposure. Do not coadminister tamsulosin-containing products with strong CYP3A4 inhibitors (GFJ) http://www.drugs.com/ppa/dutasteride-tamsulosin-hydrochloride.html

Diltiiazem
Grapefruit and grapefruit juice may interact with diltiazem and lead to potentially dangerous effects. http://www.drugs.com/diltiazem.html

PABA - Decreases breakdown of estrogen in your body so you have more free estrogen.

Coenzyme Q10: CoQ10
http://www.webmd.com/vitamins-and-supplements/lifestyle-guide-11/supplement-guide-coenzymeq10-coq10

Ramipril
http://www.drugs.com/ramipril.html
http://www.drugs.com/drug-class/angiotensin-converting-enzyme-inhibitors.html

Just some caution concerning the interactions!!!