[Eloise]

...it's modifying DNA. And that's something I'm not going do blindly nor passively.

Modifying DNA? No. Messing with your endocrine system yes, but DNA is fixed and unchangeable.

FWIW I take my estradiol before bed and 1000mg PM when I wake hoping my estrogen is high in the morning as it is in genetic females AND present to offset testosterone as Pansy-Mae said. A little in the afternoon to keep it available and that's it. I agree with others though, it's not rocket science ...but if it is no one here is a rocket scientist.

Messing with your endocrine systems messes with your RNA which in turn can mess with aspects of your DNA. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC224261/)

By the way, it was not my intention to create a kerfuffle in this thread. I was just curious as to when people took PM and what people thought of the notion of the t-cycle in relation to taking PM. All I wanted to do was generate some data that could help answer a question; not attain empathy for Copernicus.

If you like your regime and it works for you, keep your regime. It's your body. I wasn't trying to say anything to the contrary.

And I do apologize if I have come off as prickly.