[bashfluff]

Feminizing.

[elainecd]

Amazingly, local store had no peony root extract, even though they had rows and rows of Herbs of Light brand extracts. .
I ordered two bottles of the HoL brand peonia root extract (to make it worth their while) since they could get in a couple days.
I'll get the Iowa Select to have for the later.

They didn't have capsules at all. This stuff seems pretty rare.

[elainecd]

Lotus I've been skimming and reading your thread here from the beginning....and the coffee debate caught my eye, I read the Livestrong articles too.
May I chime in and comment?

I have always been a coffee drinker.....but probably 13 years ago, moved over to espresso for a couple reasons.

Being brewed quickly under pressure you get the flavor from the bean and not so much caffeine. Also the Arabica beans have less caffeine to start. Drip made coffee you get a lot more caffeine.

I usually have two separate single shots from my espresso maker (super automatic that grinds and brews) and its delicious.

I don't get caffeine over load and its pleasant to sip.
I have had employees who were young girls in their mid twenties and they go to starbucks, load up on the double caramel with crème and junk in it.....they wonder why their asses are big lol.

But any way...like so many things...the Italians do coffee right.
Ciao'

[Lotus]

Feminizing.

Bashfluff, are sure it's not bashful?

Amazingly, local store had no peony root extract, even though they had rows and rows of Herbs of Light brand extracts. .
I ordered two bottles of the HoL brand peonia root extract (to make it worth their while) since they could get in a couple days.
I'll get the Iowa Select to have for the later.

They didn't have capsules at all. This stuff seems pretty rare.

Elaine, that suggests it's flying off the shelves, lol (not likely though). So HoL carries WP, interesting, can you supply any website info?. WP Extract seems more readily available than capsules for some reason, better yield from what I gather.


Please keep us updated on the HoL results.

Thanks for checking into it.

[Lotus]

Lotus I've been skimming and reading your thread here from the beginning....and the coffee debate caught my eye, I read the Livestrong articles too.
May I chime in and comment?

I have always been a coffee drinker.....but probably 13 years ago, moved over to espresso for a couple reasons.

Being brewed quickly under pressure you get the flavor from the bean and not so much caffeine. Also the Arabica beans have less caffeine to start. Drip made coffee you get a lot more caffeine.

I usually have two separate single shots from my espresso maker (super automatic that grinds and brews) and its delicious.

I don't get caffeine over load and its pleasant to sip.
I have had employees who were young girls in their mid twenties and they go to starbucks, load up on the double caramel with crème and junk in it.....they wonder why their asses are big lol.

But any way...like so many things...the Italians do coffee right.
Ciao'

Thanks Elaine, you've made a coffee lover happy.

[Lotus]

A theory I've been working on is that a breast growth cycle should be a estrogen herb and growth hormone in the first two weeks of the cycle followed by a progesterone and prolactin source for the remainder. And here's why:

When the effect of two hormones acting together is greater or more extensive than the effect of each hormone acting alone, the two hormones are said to have a synergistic effect.

Hormones that bind to plasma membrane receptors can induce their effects at very low concentrations because they initiate a cascade or chain reaction.


Hormones affect distant cells by binding to specific receptor proteins in the target cell resulting in a change in cell function. When a hormone binds to the receptor, it results in the activation of a signal transduction pathway. This may lead to cell type-specific responses that include rapid non-genomic effects or slower genomic responses where the hormones acting through their receptors activate gene transcription resulting in increased expression of target proteins.

http://wikipedia.org/wiki/Hormone

[Lotus]

A theory I've been working on is that a breast growth cycle should be a estrogen herb and growth hormone in the first two weeks of the cycle followed by a progesterone and prolactin source for the remainder. And here's why:

When the effect of two hormones acting together is greater or more extensive than the effect of each hormone acting alone, the two hormones are said to have a synergistic effect.

Hormones that bind to plasma membrane receptors can induce their effects at very low concentrations because they initiate a cascade or chain reaction.


Hormones affect distant cells by binding to specific receptor proteins in the target cell resulting in a change in cell function. When a hormone binds to the receptor, it results in the activation of a signal transduction pathway. This may lead to cell type-specific responses that include rapid non-genomic effects or slower genomic responses where the hormones acting through their receptors activate gene transcription resulting in increased expression of target proteins.

http://wikipedia.org/wiki/Hormone

In other words affecting target tissues, (e.g. breasts).

[BestBreasts]

i've been reading different things on this website, and i'd appreciate one more from this thread please =]]

is Green Tea (preferably green tea capsules - 500mg) an anti-androgen? or does it block DHT???

thanks in advance xoxoxo

[Lotus]

i've been reading different things on this website, and i'd appreciate one more from this thread please =]]

is Green Tea (preferably green tea capsules - 500mg) an anti-androgen? or does it block DHT???

thanks in advance xoxoxo

Sorry 45 for the DHT frustration, green tea is not so cut and dry in terms of an effective DHT blocker, it depends on what research you find, meaning it's pretty confusing. If you want the short answer (which I assume is yes), I'd choose something else (e.g. reishi). According to this report its effective as a 5 ar inhibitor (blocks the conversion path to DHT). Human studies are lacking though.


Department of Biochemistry and Molecular Biology, The Ben May Institute for Cancer Research, and The Tang Center for Herbal Medicine Research MC6027, University of Chicago, 5841 S. Maryland, Chicago, IL 60637, USA.

The enzyme steroid 5 alpha-reductase (EC 1.3.99.5) catalyzes the NADPH-dependent reduction of the double bond of a variety of 3-oxo-Delta(4) steroids including the conversion of testosterone to 5 alpha-dihydrotestosterone. In humans, 5 alpha-reductase activity is critical for certain aspects of male sexual differentiation, and may be involved in the development of benign prostatic hyperplasia, alopecia, hirsutism, and prostate cancer. Certain natural products contain components that are inhibitors of 5 alpha-reductase, such as the green tea catechin (-)-epigallocatechin gallate (EGCG). EGCG shows potent inhibition in cell-free but not in whole-cell assays of 5 alpha-reductase. Replacement of the gallate ester in EGCG with long-chain fatty acids produced potent 5 alpha-reductase inhibitors that were active in both cell-free and whole-cell assay systems. Other flavonoids that were potent inhibitors of the type 1 5alpha-reductase include myricetin, quercitin, baicalein, and fisetin. Biochanin A, daidzein, genistein, and kaempferol were much better inhibitors of the type 2 than the type 1 isozyme. Several other natural and synthetic polyphenolic compounds were more effective inhibitors of the type 1 than the type 2 isozyme, including alizarin, anthrarobin, gossypol, nordihydroguaiaretic acid, caffeic acid phenethyl ester, and octyl and dodecyl gallates. The presence of a catechol group was characteristic of almost all inhibitors that showed selectivity for the type 1 isozyme of 5 alpha-reductase. Since some of these compounds are consumed as part of the normal diet or in supplements, they have the potential to inhibit 5 alpha-reductase activity, which may be useful for the prevention or treatment of androgen-dependent disorders. However, these compounds also may adversely affect male sexual differentiation.

[Lotus]

Sorry people, I have to share this rather unique way to box out DHT, I stumbled across it when I was collecting some research, please follow along (my apologies for the technical crap explanation) I'll try to keep it in the ball park.

The problem with DHT is when it enters into receptors it locks it up, and thereby making Aromatase an after thought, Aromatase is enzyme that converts free T to estrogen. (Aka boob growth), here I suggest a novel (well, at least for BN) called "Androgen Decoy's".


http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3132148_nihms255516f1.jpg



   

A transcriptional factor decoy strategy is the use of short double-stranded oligodeoxynucleotides containing a high-affinity binding site for specific transcription factors as a decoy DNA to be transfected into target cells [12–16]. Inside the cells, the decoy DNA competes with the endogenous high-affinity binding site of the target genes for binding to specific transcription factors, and consequently inhibits activated AR function [16]. Decoy DNA has potential for treatment of cardiovascular disease [12]. It also induces apoptosis in certain cell lines [13].

Androgen receptor decoy molecules block the growth of prostate cancer
http://www.pnas.org/content/104/4/1331.abstract


Androgen receptor: structure, role in prostate cancer and drug discovery
Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2–3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herei
http://www.nature.com/aps/journal/vaop/n....html#fig1