There is hope for those who despair with lack of growth (I truly believe that), everyones different, it's just a matter of finding the right combination of things.

Of which I am one 
How do you think blood type affects NBE and HRT?

There is hope for those who despair with lack of growth (I truly belive that), everyones different, it's just a matter of finding the right combination of things.

Of which I am one 
How do you think blood type affects NBE and HRT?

Great Question! !  There ya go Lotus, Sick 'Em! !

Abstract
BACKGROUND:
Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans.
METHODS:
We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.
RESULTS:
Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x10⁶/μL for the RJ group vs. -0.01x10⁶/μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).
CONCLUSIONS:
Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

With respect to the last study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499288/#!po=52.0833 


There was an increase in T but the E2/T ratio remained the same.  Is this positive for breast growth?

btw- the entire article is interesting.

I"ve tried Vacuum therapy....  Till my thumb grew an xtra inch...  Now that really SUCKS! !    Yes, puns definitely intended...  You do good work my friend.  It's just sometimes I wish I had a bio-medical degree to figure it out sometimes.    



ah..thanks. I will try to put the science in easy terms that (hopefully) explains things (e.g. NBE science).

Lotus I just have to know something. What is it like to have big breast now? I want big breast but kinda afraid what people would think of me around here. I feel soooooo trapped

oh boy, ask me something easy, lol. Well, having breasts is why we're all here right?, so for me it feels like I should've had breasts all along..or been born female.

Two things happen meeting new people, meaning they'll look me in the face and then down to my boobs (and a couple times just boobs). So...you can either get paranoid about it or simply ignore the looks and go about life. I must be pretty boring, (or my T is in the tank) but i don't find having breasts as a particular fetish, but that's just me, I completely understand why people lose their minds and oogle and get weak in the kness about wanting breasts.

Friends and family (and others) will definitely see the change as one grows breasts, here again, you can let people's opinion bother you or live life...a good friend gave me some good advice (about having boobs and transition) and she simply stated to enjoy what i have at present, don't obsess over the stuff (NBE/Hrt) that hasn't happened yet....bottom line? press foward and rock what u got baby.

There is hope for those who despair with lack of growth (I truly believe that), everyones different, it's just a matter of finding the right combination of things.

Of which I am one 
How do you think blood type affects NBE and HRT?

Great Question! !  There ya go Lotus, Sick 'Em! !

that is a great question, I don't think we've ever factored blood types into NBE/Hrt, here's what I found.

type A & AB have higher levels of cortisol, and generally, cortisol (if not used properly)  will hurt breast growth, in other words, Type O blood produces less cortisol (less of an obstacle for breast growth). Putting high stress (which sends cortisol super sonic in the wrong direction) to work for us means exercise...and I mean HIIT (high intensity interval training). The repair peptides unleashed by HIIT are (sic) unbleivable, and supplementing NBE/Hrt post workout (with growth promoting proteins)....e.g. whey protein or casein, plus NBE herbs or HRT takes breast growth to the next level. i prefer casein + glycine.+ collagen w/vitamin D, L-tyrosine, glutamine plus E2/MSM and Spiro.

here's one example (below) on using glycine (prolin is also pro breast growth too). Essentially, whats missing in NBE/Hrt is growth hormone/IGF-....or rather stimulating the two IN combination with E2. In combination therapy (for NBE/Hrt) everything work simultaneously....mutiple studies have already proved that combo therapy produces better results over standard single delivery (which I believed 2-3 years ago single use delivery was the gold  standard, not amymore). 

 Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1
https://www.researchgate.net/publication/260841801_Cyclic_glycine-proline_regulates_IGF-1_homeostasis_by_altering_the_binding_of_IGFBP-3_to_IGF-1

In this cohort study below a sampling of blood types revealed how different blood hormone status effects cancer types.

Blood Type, Hormone Receptor Status, HER2/neu Status, and Survival in Breast Cancer: A Retrospective Study Exploring Relationships in a Phenotypically Well-Defined Cohort
www.ncbi.nlm.nih.gov/pmc/articles/PMC3251447/

Persons with blood type B (83.7%) and blood type A (75.7%) had smaller tumors (<2cm on average) than persons who were blood type AB (68.2%) or blood type O (61.7%).

The presence of progesterone receptors demonstrates an active ER mechanism for the induction of PR expression. Notably, blood group B individuals also exhibited the highest rates of ER/PR positivity which is considered a favorable prognostic factor in breast carcinoma.

so what's the take away here?....my opinion?...the antigens in blood types (or lack thereof) needs to be better explored and defined for NBE/Hrt. Though the conclusion of the study states the follwing.


Conclusion No significant differences were observed in overall and disease-free survival based on blood group. No correlation was noted between HER2/neu, ER or PR status, and blood group type. Among this cohort, HER2/neu positivity was less than 20% and correlated with a 5-year disease-free survival rate ≥75% and overall survival of >80% across all blood groups.

I"ve tried Vacuum therapy....  Till my thumb grew an xtra inch...  Now that really SUCKS! !    Yes, puns definitely intended...  You do good work my friend.  It's just sometimes I wish I had a bio-medical degree to figure it out sometimes.    



ah..thanks. I will try to put the science in easy terms that (hopefully) explains things (e.g. NBE science).

Lotus I just have to know something. What is it like to have big breast now? I want big breast but kinda afraid what people would think of me around here. I feel soooooo trapped

oh boy, ask me something easy, lol. Well, having breasts is why we're all here right?, so for me it feels like I should've had breasts all along..or been born female.

Two things happen meeting new people, meaning they'll look me in the face and then down to my boobs (and a couple times just boobs). So...you can either get paranoid about it or simply ignore the looks and go about life. I must be pretty boring, (or my T is in the tank) but i don't find having breasts as a particular fetish, but that's just me, I completely understand why people lose their minds and oogle and get weak in the kness about wanting breasts.

Friends and family (and others) will definitely see the change as one grows breasts, here again, you can let people's opinion bother you or live life...a good friend gave me some good advice (about having boobs and transition) and she simply stated to enjoy what i have at present, don't obsess over the stuff (NBE/Hrt) that hasn't happened yet....bottom line? press foward and rock what u got baby.

I guess I could not lie and just blame it on the herbs I take that will make me more fem.

Looking Great lotus, and sitting tight for that update. This girl needs to know your secret!

right, so sorry for they delay. Tbh, it's a sticky mess but worth the effort for enhanced areolas. It's called " Royal Jelly "....I find applying RJ to areolas to benefit the size and shape of areolas....also breasts if one is willing to manage the mess. Application is sticky..(did I mention that already,lol) use a food grade platstic wrap per area and let it overnight...in the morning nearly all the RJ is absorbed, shower and see results either immediately or throughout the day. This may/or may not work for everyone, it is pollen after all. 

As time permits I will be posting new evidence about how IGF-1 (insulin growth factor) and E2 (estradiol) is the next revolution in breast growth. 


J Med Food. 2012 Jun;15(6):568-75. doi: 10.1089/jmf.2011.1888. Epub 2012 Apr 2.
Royal jelly increases collagen production in rat skin after ovariectomy.

Park HM1, Cho MH, Cho Y, Kim SY.
Author information
Abstract
Royal jelly (RJ) is a honeybee product that contains proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. RJ has been reported to have antitumor, antibacterial, and wound-healing activities. We previously reported that RJ enhanced the migration of human dermal fibroblasts and altered the levels of cholesterol and sphinganine in an in vitro wound-healing model in addition to regulating skin photoaging following exposure to ultraviolet-B radiation. We established an animal model of skin aging in the context of estrogen deficiency and assessed the antiaging effects of RJ on skin. To establish an in vivo model of skin aging, bilateral ovariectomies were performed in 12-week-old virgin female Sprague-Dawley rats. Induction of osteoporosis was confirmed through two-dimensional images of the trabecular bone in the left femoral necks using microcomputed tomography. The protective effects of RJ ovariectomy-induced skin aging were examined by determining the protein expression of type I procollagen and matrix metalloproteinase (MMP)-1. The collagen content and epidermal thickness of skin tissue were measured by staining techniques. There was a significant difference in weight between sham-operated and ovariectomized groups. Food efficiency ratio did not differ significantly among the groups. The level of procollagen type I protein was increased in the dorsal skin of ovariectomized rats fed with a dietary supplement containing 1% RJ extract, but the level of MMP-1 was not altered. In particular, the amount of collagen recovered was close to the normal level. RJ may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency.
PMID: 22468645 PMCID: PMC3359633 DOI: 10.1089/jmf.2011.1888
[Indexed for MEDLINE] Free PMC Article


Bioactive compounds and health-promoting properties of royal jelly: A review 
http://medicata.lt/wp-content/uploads/2015/06/Bioactive-compounds-and-health-promoting-properties-of-royal-jelly_A-review.pdf


Fatty acids derived from royal jelly are modulators of estrogen receptor functions.
Moutsatsou P1, Papoutsi Z, Kassi E, Heldring N, Zhao C, Tsiapara A, Melliou E, Chrousos GP, Chinou I, Karshikoff A, Nilsson L, Dahlman-Wright K.
Author information

Abstract
Royal jelly (RJ) excreted by honeybees and used as a nutritional and medicinal agent has estrogen-like effects, yet the compounds mediating these effects remain unidentified. The possible effects of three RJ fatty acids (FAs) (10-hydroxy-2-decenoic-10H2DA, 3,10-dihydroxydecanoic-3,10DDA, sebacic acid-SA) on estrogen signaling was investigated in various cellular systems. In MCF-7 cells, FAs, in absence of estradiol (E(2)), modulated the estrogen receptor (ER) recruitment to the pS2 promoter and pS2 mRNA levels via only ERβ but not ERα, while in presence of E(2) FAs modulated both ERβ and ERα. Moreover, in presence of FAs, the E(2)-induced recruitment of the EAB1 co-activator peptide to ERα is masked and the E(2)-induced estrogen response element (ERE)-mediated transactivation is inhibited. In HeLa cells, in absence of E(2), FAs inhibited the ERE-mediated transactivation by ERβ but not ERα, while in presence of E(2), FAs inhibited ERE-activity by both ERβ and ERα. Molecular modeling revealed favorable binding of FAs to ERα at the co-activator-binding site, while binding assays showed that FAs did not bind to the ligand-binding pocket of ERα or ERβ. In KS483 osteoblasts, FAs, like E(2), induced mineralization via an ER-dependent way. Our data propose a possible molecular mechanism for the estrogenic activities of RJ's components which, although structurally entirely different from E(2), mediate estrogen signaling, at least in part, by modulating the recruitment of ERα, ERβ and co-activators to target genes.


Royal jelly has estrogenic effects in vitro and in vivo.
Mishima S1, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T.

Author information
Abstract
Royal jelly (RJ) from honeybees (Apis mellifera) is traditionally thought to improve menopausal symptoms. The potential estrogenic activities of RJ were investigated using various approaches. RJ competed for binding of 17beta-estradiol to the human estrogen receptor alpha and beta but its affinities were weak compared with diethylstilbestrol and phytoestrogens. The reporter gene expression assays suggested that 0.1-1 mg/ml RJ activated estrogen receptors, leading to enhanced transcription of a reporter gene through an estrogen-responsive element. 1 mg/ml RJ stimulated the mRNA expression of estrogen-responsive pS2 and vascular endothelial growth factor (VEGF) by increasing gene transcription in MCF-7 cells. Treatment with RJ at concentrations ranging from 0.5 to 1 mg/ml enhanced MCF-7 cell proliferation, but concomitant treatment with 1 microM tamoxifen blocked this effect. In vivo studies using ovariectomized rats showed that 17beta-estradiol (20 mg/kg, s.c.) treatment restored VEGF expression in both uterus and brain, whereas RJ (1 g/kg, s.c.) restored it in uterus but not in brain. These findings provide evidence that RJ has estrogenic activities through interaction with estrogen receptors followed by endogenous gene expressions.
PMID: 15946813  DOI: 10.1016/j.jep.2005.04.012


Effect of royal jelly ingestion for six months on healthy volunteers.

Morita H1, Ikeda T, Kajita K, Fujioka K, Mori I, Okada H, Uno Y, Ishizuka T.

Author information

Abstract
BACKGROUND:
Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans.
METHODS:
We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.
RESULTS:
Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x10⁶/μL for the RJ group vs. -0.01x10⁶/μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).
CONCLUSIONS:
Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

With respect to the last study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499288/#!po=52.0833 


There was an increase in T but the E2/T ratio remained the same.  Is this positive for breast growth?

btw- the entire article is interesting.

hi Alexis,

thanks for the question. Frankly, T doesn't spook me because a majority of it isn't bio-available.

Estradiol (E2) is more important than testosterone in the pathway to insulin resistance in healthy, young postmenopausal women [20].

fixing insulin resistance is empirical to productive breast growth, then followed by a less acidic environment the gut, instead... .promote an alkaline environment, also invest in a established pro-biotics.

anyways lol, don't get hung up on that first part of the paragraph. To me, the begining of the paragraph suggests that putting RJ on the testes will promote aromatase.

E2 is a primary estrogen in humans and is converted from T by aromatase located in the ovary or adipose tissues. Most of our female participants were over the age of 50 and after menopause, resulting in lower serum E2 levels in women than those in men. DHEA-S is the most abundant androgen in human beings and is synthesized in the adrenal. It is then converted to T through androstenedione by 3β-hydroxysteroid dehydrogenase type 2 (3β-HSD2) and 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) located in the adrenal and testis [25]. In the present trial, less increase in DHEA-S and more increase in T in the RJ group than in the control one was observed, suggesting that RJ may have induced the conversion of DHEA-S to T by stimulating 3β-HSD2 and/or 17β-HSD3 as shown in Figure Figure2.2. Serum T/DHEA-S and E2/T ratios are considered to be designated activities of 3β-HSD2 and/or 17β-HSD3 and aromatase, respectively. The changes of log T/DHEA-S ratio were significantly higher only in the men, suggesting that RJ may induce 3β-HSD2 and/or 17β-HSD3 activity in the testis. It is possible that RJ also could promote those enzyme activities in the ovary if the women had normal menstrual cycles. In contrast, the changes of log E2 and log E2/T ratios were not different, indicating that RJ may have no action on aromatase in human beings. The enhanced 3β-HSD2 and/or 17β-HSD3 activity may result from high antioxidant enzyme activities of RJ [26].

to answer your question, we shouldn't overlook following (or inducing) 3β-HSD2 and/or 17β-HSD3 pathway, because of the potential of aromtase.....in other words, it's benefiting breast growth.

type A & AB have higher levels of cortisol, and generally, cortisol (if not used properly)  will hurt breast growth, in other words, Type O blood produces less cortisol (less of an obstacle for breast growth). Putting high stress (which sends cortisol super sonic in the wrong direction) to work for us means exercise...and I mean HIIT (high intensity interval training). The repair peptides unleashed by HIIT are (sic) unbleivable, and supplementing NBE/Hrt post workout (with growth promoting proteins)....e.g. whey protein or casein, plus NBE herbs or HRT takes breast growth to the next level. i prefer casein + glycine.+ collagen w/vitamin D, L-tyrosine, glutamine plus E2/MSM and Spiro.


I am ectomorph body type with AB+ blood type. Would HIIT and cardio not be counterproductive then? If I understand correctly, by exercising I can raise my naturally high cortisol level and send it in the wrong direction, but at the same time reduce my scarce fat resources even more. Having some weight would certainly add value to my goals of breast growth & fat redistribution.

I am screwed, and not in a good way either - haha

type A & AB have higher levels of cortisol, and generally, cortisol (if not used properly)  will hurt breast growth, in other words, Type O blood produces less cortisol (less of an obstacle for breast growth). Putting high stress (which sends cortisol super sonic in the wrong direction) to work for us means exercise...and I mean HIIT (high intensity interval training). The repair peptides unleashed by HIIT are (sic) unbleivable, and supplementing NBE/Hrt post workout (with growth promoting proteins)....e.g. whey protein or casein, plus NBE herbs or HRT takes breast growth to the next level. i prefer casein + glycine.+ collagen w/vitamin D, L-tyrosine, glutamine plus E2/MSM and Spiro.


I am ectomorph body type with AB+ blood type. Would HIIT and cardio not be counterproductive then? If I understand correctly, by exercising I can raise my naturally high cortisol level and send it in the wrong direction, but at the same time reduce my scarce fat resources even more. Having some weight would certainly add value to my goals of breast growth & fat redistribution.

I am screwed, and not in a good way either - haha

it's quite the opposite, a high strung individual could have high cortisol due to stress, diet and meditation help, but exercise settles the extra cortisol.....cataboilc exercise is ok, but doesn't produce those repair peptides for new growth....anaboilc exercise is what i mean, which only needs to be performed a few times a week, and in short durations, post workout is when to supplement with the NBE arsenal.

it's quite the opposite, a high strung individual could have high cortisol due to stress, diet and meditation help, but exercise settles the extra cortisol.....cataboilc exercise is ok, but doesn't produce those repair peptides for new growth....anaboilc exercise is what i mean, which only needs to be performed a few times a week, and in short durations, post workout is when to supplement with  the NBE arsenal.

Thanks for the input and the effort.