Very hopeful to learn other tricks for enhancing somatotropin, or curtailing somatostatin.
I've used 3 mg. melatonin, 250 mg. CDP-choline, and Phosphatidylcholine for years. I didn't notice it made any difference. Even though I lift weights daily, I'm fairly locked in at my high-school weight and musculature. I've always figured it was the statin holding me back.
This post is for anyone wishing to lactate.
Prolactin is basically stimulated by the paraventricular nucleus via the hypothalamus, (I won't describe prolactin inhibiting hormone because dopamine is the same thing). Basically Thyrotropin Releasing Hormone (TRH) is essentially passed on by the anterior pituitary to be released the lactotrope cell inside the anterior pituitary and on out via blood supply.
Things needed to produce breast milk:
1) Estrogen
2) Inhibiting dopamine
3) TRH- Thyrotropin releasing hormone
4) Breast feeding (some BN members use pumps, use the BN search to find threads).
What's cool is that when dopamine is inhibited the secretion of Adenylyl Cyclase is stimulated (much in the same way alcar works) to stimulate ATP production. But...that pesky PDE stops ATP synthesis in the mitochondria, unless we use a PDE inhibitor.
So D1 agonists (promoters) inhibit dopamine (D2 inhibitors are too risky to use). Which in this case D1 agonists stimulates protein kinase C (PKC), in other words PKC stimulates aromatase too. My plan is skipping inhibiting dopamine and stimulating it with PKC, sorta leapfrogging dopamine, it's already been proven. There's a PKC promoter that fits the bill. Since D1 agonists stimulate Adenyl Cyclase which then produces ATP and aromatase we don't need dopamine for stimulating prolactin because dopamine is messy.
Inhibiting dopamine raises prolactin. Estrogen raises prolactin too, but high levels of estrogens inhibit prolactin. In the process of prolactin stimulation alveolar glands (lobules) get bigger. Ironically MSM stimulates what's known as the Jak2/STAT pathway, and this pathway stimulates alveolar glands (housed inside the lobules) via the portal blood system...this is good as it helps with protein synthesis. We need further protein synthesis of alveolar glands to generate such things as Iga-1, milk proteins, vitamins, cholesterol, lactoferrin (etc) so that breast milk can be produced. We also need ATP in this protein synthesis, but that goes back to describing the citric acid cycle (aka krebs cycle), lol, that's covered in an earlier post.
Once protein synthesis is released to lumen then its on the way out of the lactiferous ducts to express milk.
So, if you take an antidepressant, thyroid medication, or estrogen you're almost there. The PKC (protein kinase C) is Forskolin. but, not all Forskolin is created equal.
I can see MSM playing a part here. I don't have the particular dosages needed on estradiol, MSM or antidepressants or forskolin just yet. But I do see forskolin as an herbal replacement for estradiol as it being a pro-aromatase herb.
@ troublewithnibbles- from experience not all melatonin is created equal too, meaning some seem more effective than others.
@ AWOO, you're welcome, and good to see you posting again.
@ Pleasantlyfascinated, lol, I'm on it.
Thanks, LT. If I could only remember my old login, that would be cool. Until then, I’ll just AWOO. But, that being said, I think the abstract of the Cimetidine study says to take 800mg, twice a day. Tbh, that’s too much for me. I say that, as the studies I read about Cimetidine and Gynecomastia were long term use doctor prescribed doses of 1,600mg for Antacid, produced a flood of prolactin and elevated rates of Gynecomastia. I’ll have to refer back to those studies, but these effects were notated at between doses of 800mg and 1600mg. I tried this several times, but I could only last a week at a time due to “sex organ weight reduction”. Plus, since the range of doses were 800-1600, I took 1,000. Any more is a waste of money as the stuff isn’t cheap and elevated and prolonged use can inhibit liver function, and it just ain’t worth it.
I’m a little confused about a Cimetidine’s role in all this. Are you saying it inhibits Somatostatin?
There’s several other stomach acid drugs available, but I do keep Cimetidine in the cabinet for all it’s known properties. I only take it now for it’s intended use, though. And certainly not at elevated doses anymore. Tbh, the few times I experimented with it, shrank my package. And it never recovered. Not too happy about that, tbh.
I tried the melatonin (3mg with gaba and theanine) that I had on hand 2 nights ago along with only a half dose of forskolin and a dose of GTE. Woke up 3 hours later tingling in the usual growth areas and had the biggest erection I’ve had in several months. All I can say is wow!
(20-07-2020, 03:02 AM)Lotus Wrote: [ -> ] (19-07-2020, 04:46 AM)Troublewithnibbles Wrote: [ -> ]
I tried the melatonin (3mg with gaba and theanine) that I had on hand 2 nights ago along with only a half dose of forskolin and a dose of GTE. Woke up 3 hours later tingling in the usual growth areas and had the biggest erection I’ve had in several months. All I can say is wow!
Wow indeed. That must've been one helluva dream lol. Good choice on adding gaba, though the forskolin and GTE would keep me up all night. Try adding MSM 2g and vitamin D3 (4000IU) to the gaba and melatonin. MSM and vitamin D3 aid in synthesis of alveolar glands inside the lobules of the breasts. In other words...milk ducts.
I tried as you suggested without the forskolin and gte and with the msm and d3. Same effect. I wonder why.
Well, working nights means sleep is generally poor. Oddly enough, I got almost 7 solid hours this morning and I actually didn’t take anything beforehand. I don’t really take any pharmaceuticals.
