Let's say BO does what it's advertised, hopefully it would work in tandem with PC, as the study below points out. I think the triglycerides both in PC and BO produce lipase activity, which catalyzes the hydrolysis of fats.
Studies in adipose tissue showed that treatment with ethynyl estradiol and progesterone, separately or in combination, increased lipoprotein lipase activity to a comparable extent. After treatment with progesterone alone, the increase was observed in the absence of elevated levels of triglycerides in blood. Triacylglycerol lipase activity assayed at pH 7.4 (hormone- sensitive lipase) was not affected by ethynyl estradiol or progesterone alone, but a significant decrease was observed under a combined regimen. None of these hormonal treatments modified the level of monoester lipase activity.
Taken together, the results point to major hormonal influences on lipid metabolism in liver and adipose tissue. However, it cannot be assessed whether these effects are due to the direct action of ethynyl estradiol and progesterone on liver and adipose tissue lipases and/or to some other altered metabolic response (s) secondary to the intake of the steroids.
- See more at:
http://press.endocrine.org/doi/abs/10.12...QzX1p.dpuf
(19-05-2016, 12:31 AM)Lotus Wrote: [ -> ]Let's say BO does what it's advertised, hopefully it would work in tandem with PC, as the study below points out. I think the triglycerides both in PC and BO produce lipase activity, which catalyzes the hydrolysis of fats.
Studies in adipose tissue showed that treatment with ethynyl estradiol and progesterone, separately or in combination, increased lipoprotein lipase activity to a comparable extent. After treatment with progesterone alone, the increase was observed in the absence of elevated levels of triglycerides in blood. Triacylglycerol lipase activity assayed at pH 7.4 (hormone- sensitive lipase) was not affected by ethynyl estradiol or progesterone alone, but a significant decrease was observed under a combined regimen. None of these hormonal treatments modified the level of monoester lipase activity.
Taken together, the results point to major hormonal influences on lipid metabolism in liver and adipose tissue. However, it cannot be assessed whether these effects are due to the direct action of ethynyl estradiol and progesterone on liver and adipose tissue lipases and/or to some other altered metabolic response (s) secondary to the intake of the steroids.
- See more at: http://press.endocrine.org/doi/abs/10.12...QzX1p.dpuf
interesting..very very interesting
Can we call up the signal of E2 (estradiol) whenever we'd like?, I think it's a distant possibility. Greetings fellow boob lovers
, as we know E2 is stored in aromatase and in SHBG (sex hormone binding globulin).
Dht has a 4x affinity in SHBG over estradiol, something that lowers DHT in SHBG is increased body temperature. My idea would be to displace DHT from SHBG by way of free energy binding of estradiol. Up to 95% of hormones, fatty acids are bound in plasma, and SHBG carries hormones to tissues, and........on another note steroid synthesis occurs in peripheral tissue(s).......i.e. breast, adipose, testes.
Getting back to free energy binding, I believe (to a certain extent) that this (F.E.B.) takes place in a few reactions (thermogenesis, release of leptin, fasting, and possibly the adrenocorticotropic hormone (ACTH) inside our bodies. But, by raising our body temp we lower DHT in SHBG and free up E2 (the calling up of E2).
There is an exact sequence on how this goes imo, but it's tied to metabolism, a few other things too. I'll explain more in detail soon, I just wanted to share some exciting prospects.
Here's a thread I started but never got around to finishing, it outlines the very essence of this theory:
Metabolism and Hormones
http://www.breastnexus.com/showthread.php?tid=22831
Hey thank you so much and I am sorry for the long delay!!!! So basically to start you started with the herbs and that actually gave you some growth? I didn't read everything but I'm out of town on my phone and I'll look at it all when I get back home. Thank you for that story!!!! I am actually thinking about quitting bo. I might get PM cream and just take saw palmetto
(17-05-2016, 01:24 AM)Lotus Wrote: [ -> ] (16-05-2016, 01:54 AM)sabrielx92 Wrote: [ -> ]You seem to know a lot Lotus and I envy what you have accomplished! When you first started NBE did you have a flat chest? if so, what did you do to get breast growth? Also, what is SP and PC?
Hi sabriel,
I did start with what we could call a typical male chest (ok, flat lol). When I started developing breast tissue (pre NBE) I was concerned and made an appt. to see my now former PCP of 12 years. Very nice Dr. [90 yrs. young lol], though very old school.
Anyways.......are you sure you want to hear about this? 
cause there will blood ((haha)), pain, self doubt & torture (true), and perhaps lack of proper guidance, but nothing more than a few visits (3-4 different shrinks actually) would cure huh?. Oh wait!, then there was the visit to the endo (jerk) who discouraged my path, which I think led to a dark period (1.5 yrs actually) ultimately that led me to my current doc (finally, a trans friendly Physician). Btw, the endo suggested I remove the breat tissue 
, that's after he said " yep, those are real female breasts. At the time my GID was heavy gender fluid, and when I mention it to him (the gender fluid) he became very annoyed at the mere mention of it, his quote " there's no such things, I don't believe in the gender variants, it's either your full transition or nothing ".........so I thought to myself ( " oh hell no, you mf'er " you just discriminated against me). 
And although some part of me told me to take his shitty advice it pushed me to a dark place that ended up going to DIY hormones, dangerous times indeed. As for the endo, I got a nice letter announcing his retirement shortly after. I wonder how many TG folks got his shitty care?. I was seeing (still am, no anti-depressants though) a shrink, number 4 (a great guy too), he found my current TG doc.
Getting back to pre-NBE (which wasn't even on the radar at the time) sent me for a mammogram, and was diagnosed with gyno (gynecomastia). So.......naturally seeking more info I jumped on the " World Wide Web " and found breast nexus, which I found inspiration from flamsabers, technical guidance from Abidrew and Isabelle. At that point I had what you would call puffy nipples, but the more important question is why did I want this path????, well, I still have my doubts about that, although I lean towards the thought my GID lay dormant (for years) and with the start of NBE, the walls (bells rang lol) came crashing down I guess. 
I started with the typical NBE program of RC (red clover), FG (fenugreek) SP (saw palmetto), PC (progesterone cream), I stayed with that for about 6-8 months (if I remember correctly) which yielded about 1 cup increase. The next program i went with PM capsules (pueraria mirifica) add 1 cup more. I experimented with BO (w/disastrous infections) e.g. damaged my right eye permanently (a retinal hemorrhage, aka blood) requiring laser eye surgery to plug the leak. Add in a major ear/jaw infection, a trip to the ER for an acute bout of colitis, which was followed by a colonoscopy (btw, the prep was god awful) to rule out further problems. Which is the reason why I won't recommend BO (bovine ovary).
The 3-4th NBE program I went to extracts (for the most part), and then modified with different anti-androgens & pro aromatase supps........add 1-2 cups more growth from those mods. My idea (or thought process was to keep pushing with breast growth and some feminization), lol which obviously went further then expected ok. As I battled with GID, the two sides (male/female) clashed (still an epic throw down though) the female side demand(s) more control lmao, so call it what you will, meaning a two-spirit??, or non-binary gender/ gender fluid???, I'm still working on that part but I'm on path of transition, hey it works (or is working) for now. I will eventually add some essence to the female side (short term?? 3-6 months??? not sure), but I surely don't look like I did 2-3 years ago. Will I need cosmetics, maybe? maybe not, will see what HrT does in the near term first.
Sheesh, this has been therapeutic, thanks sabriel, I usually don't go this deep about myself lol (too boring imo lol) sorry for the long drawn out. whatever path you (we) take, finding the right care sometimes take a tortuous path (or journey) to find them (unfortunately). And sadly, good people are lost forever in this maddening process to find the right medical care, it needs to be fixed.
O, I did have a couple early puffy nipple pics up, but in a major dust up (here at BN) back in the day they were deleted (by me) (perhaps a discussion for another day). 
This is so refreshing to read one's struggle and path you took . It not helps you unload some suppressed grief and also helps other who are in similar situation and your experience can help a little towards the guidance .
thank you so much for this, lotus!
(19-05-2016, 12:49 AM)Tanya Marie Squirrel Wrote: [ -> ]interesting..very very interesting
and yes, it is! thank you for that as well, lotus (the BO statement) I was going to try BO as my last and final attempt a NBE if, at the end of my NBE journey I am still not where I want to be. (as far as growth and symmetry)
(21-05-2016, 11:47 PM)sabrielx92 Wrote: [ -> ]Hey thank you so much and I am sorry for the long delay!!!! So basically to start you started with the herbs and that actually gave you some growth?
No worries.
yes, (in my case) the first NBE program I used launched the basic platform for more breast growth.
(22-05-2016, 12:34 AM)myboobs Wrote: [ -> ]This is so refreshing to read one's struggle and path you took . It not helps you unload some suppressed grief and also helps other who are in similar situation and your experience can help a little towards the guidance .
Roger that myboob-dude
some personal perspective is always nice to hear about, and lol, I struggle too.
(22-05-2016, 02:33 AM)missboobshirt Wrote: [ -> ]thank you so much for this, lotus!
(19-05-2016, 12:49 AM)Tanya Marie Squirrel Wrote: [ -> ]interesting..very very interesting
and yes, it is! thank you for that as well, lotus (the BO statement) I was going to try BO as my last and final attempt a NBE if, at the end of my NBE journey I am still not where I want to be. (as far as growth and symmetry)
Ah lol, it's about to get more..........interesting.
Missb, funny you should mention BO?. In this study researchers found:
The " high affinity binding site is present only in the mature endometrium and is absent in nuclei from the mature myometrium (the muscular tissue surrounding the endometrium in the uterus) and the immature uterus. "
The Binding of Estradiol-17b to the Bovine Endometrial Nuclear Membrane*
http://m.jbc.org/content/249/5/1615.full.pdf
The NBE bioavailability of bovine ovary will be dependent on the estrous cycle (and when it was harvested).......if any.
(22-05-2016, 06:51 AM)Lotus Wrote: [ -> ] (22-05-2016, 02:33 AM)missboobshirt Wrote: [ -> ] (21-05-2016, 05:59 AM)Lotus Wrote: [ -> ]Can we call up the signal of E2 (estradiol) whenever we'd like?, I think it's a distant possibility. Greetings fellow boob lovers , as we know E2 is stored in aromatase and in SHBG (sex hormone binding globulin).
Dht has a 4x affinity in SHBG over estradiol, something that lowers DHT in SHBG is increased body temperature. My idea would be to displace DHT from SHBG by way of free energy binding of estradiol. Up to 95% of hormones, fatty acids are bound in plasma, and SHBG carries hormones to tissues, and........on another note steroid synthesis occurs in peripheral tissue(s).......i.e. breast, adipose, testes.
Getting back to free energy binding, I believe (to a certain extent) that this (F.E.B.) takes place in a few reactions (thermogenesis, release of leptin, fasting, and possibly the adrenocorticotropic hormone (ACTH) inside our bodies. But, by raising our body temp we lower DHT in SHBG and free up E2 (the calling up of E2).
There is an exact sequence on how this goes imo, but it's tied to metabolism, a few other things too. I'll explain more in detail soon, I just wanted to share some exciting prospects.
Here's a thread I started but never got around to finishing, it outlines the very essence of this theory:
Metabolism and Hormones
http://www.breastnexus.com/showthread.php?tid=22831
thank you so much for this, lotus!
(19-05-2016, 12:49 AM)Tanya Marie Squirrel Wrote: [ -> ]interesting..very very interesting
and yes, it is! thank you for that as well, lotus (the BO statement) I was going to try BO as my last and final attempt a NBE if, at the end of my NBE journey I am still not where I want to be. (as far as growth and symmetry)
Ah lol, it's about to get more..........interesting.
Missb, funny you should mention BO?. In this study researchers found:
The " high affinity binding site is present only in the mature endometrium and is absent in nuclei from the mature myometrium (the muscular tissue surrounding the endometrium in the uterus) and the immature uterus. "
The Binding of Estradiol-17b to the Bovine Endometrial Nuclear Membrane*
http://m.jbc.org/content/249/5/1615.full.pdf
The NBE bioavailability of bovine ovary will be dependent on the estrous cycle (and when it was harvested).......if any.
that makes a lot of sense. might be why it doesn't work for some...
I know a few here have fibromyalgia, a 2010 study showed how short bursts of exercise can help reduce pain. That's the issue, getting past the initial threshold of pain. I'll say this about FM
Get determined and take control of that pain before it sidelines you for good, don't let life pass you by. !!
(psa out).
Fibromyalgia symptoms improved by lifestyle adjustments
BioMed Central
Summary:
Short bursts of physical activity can ease fibromyalgia symptoms. Researchers writing in BioMed Central's open access journal Arthritis Research & Therapy have shown that encouraging patients to undertake 'Lifestyle Physical Activity' (LPA) can markedly increase the average number of steps taken per day and produce clinically relevant reductions in perceived disability and pain.
http://www.sciencedaily.net/releases/201...203230.htm
Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia: secondary exploratory analyses from a randomized controlled trial
http://arthritis-research.biomedcentral....016-1007-0