Breast Growth For Genetic Males

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(10-01-2015, 09:02 PM)Lotus Wrote: [ -> ]Congrats on going full-time, Smile

It's definitely a struggle towards finding the balance. Some prescribed meds have unintended consequences Dodgy which sucks when they conflict with current goals.

Pharmacology is fascinating to me, a meh!, and for some it's" just gimme the stuff" lol which cool cause I was that way too at one time or another. Rolleyes

Maybe someone can help you prepare meals in advance, I know I know, easier said than done, just a thought. Cuke's and peppers are great, (red & yellow for sure), pepper on the cuke's for antioxidants, or parsley, oregano, even cilantro. Or throw in a twist with Greek yogurt. Big Grin a nighty cap of protein and GH. Wink

It's going to be hard for me personally because I'm currently a senior in college, and it's hard to eat right when the campus cafeteria only ever serves weird tasting burgers, pizza, fries, hot dogs, and grilled cheese. Dodgy
(16-01-2015, 12:02 AM)BlueCoral Wrote: [ -> ]
(10-01-2015, 09:02 PM)Lotus Wrote: [ -> ]Congrats on going full-time, Smile

It's definitely a struggle towards finding the balance. Some prescribed meds have unintended consequences Dodgy which sucks when they conflict with current goals.

Pharmacology is fascinating to me, a meh!, and for some it's" just gimme the stuff" lol which cool cause I was that way too at one time or another. Rolleyes

Maybe someone can help you prepare meals in advance, I know I know, easier said than done, just a thought. Cuke's and peppers are great, (red & yellow for sure), pepper on the cuke's for antioxidants, or parsley, oregano, even cilantro. Or throw in a twist with Greek yogurt. Big Grin a nighty cap of protein and GH. Wink

It's going to be hard for me personally because I'm currently a senior in college, and it's hard to eat right when the campus cafeteria only ever serves weird tasting burgers, pizza, fries, hot dogs, and grilled cheese. Dodgy

Yeah that's no good, do they offer any fruits or salads?. Do you like walnuts?, if so make some snack baggies, I throw in some real dark chocolate morsels (in moderation though, a rich flavonoid).

Walnuts are great for NBE,

Walnuts
http://www.whfoods.com/genpage.php?tname=foodspice&dbid=99
(16-01-2015, 12:25 AM)Lotus Wrote: [ -> ]
(16-01-2015, 12:02 AM)BlueCoral Wrote: [ -> ]
(10-01-2015, 09:02 PM)Lotus Wrote: [ -> ]Congrats on going full-time, Smile

It's definitely a struggle towards finding the balance. Some prescribed meds have unintended consequences Dodgy which sucks when they conflict with current goals.

Pharmacology is fascinating to me, a meh!, and for some it's" just gimme the stuff" lol which cool cause I was that way too at one time or another. Rolleyes

Maybe someone can help you prepare meals in advance, I know I know, easier said than done, just a thought. Cuke's and peppers are great, (red & yellow for sure), pepper on the cuke's for antioxidants, or parsley, oregano, even cilantro. Or throw in a twist with Greek yogurt. Big Grin a nighty cap of protein and GH. Wink

It's going to be hard for me personally because I'm currently a senior in college, and it's hard to eat right when the campus cafeteria only ever serves weird tasting burgers, pizza, fries, hot dogs, and grilled cheese. Dodgy

Yeah that's no good, do they offer any fruits or salads?. Do you like walnuts?, if so make some snack baggies, I throw in some real dark chocolate morsels (in moderation though, a rich flavonoid).

Walnuts are great for NBE,

Walnuts
http://www.whfoods.com/genpage.php?tname=foodspice&dbid=99

Thankfully they do have a REALLY small salad bar, though I think they only threw it in there so they wouldn't get in trouble for just serving cheap greasy stuff LOL. They might have walnuts, I'll have to have a closer look later tonight.
(19-09-2014, 02:06 AM)Lotus Wrote: [ -> ]http://www.pricklypearjunction.com/inter...ogical.htm

Summary

Gynecological Herbs

introduction:
Traditionally, a large number of different herbs have been used to affect different aspects of the activity of the female reproductive tract. Historically, there is a legacy of confusion and little agreement even among contemporary authorities about the precise meaning of different designations and classifications of herbs used in gynecology. For a review of author discrepancies see The Phytoestrogen Debate by Peggy Wilbur, and for a historical review of herbs used in gynecological conditions see A Comparative Review of Eclectic Female Regulators by Francis Brinker. Endocrine-like activities of herbs used for gynecological purposes do not necessarily correspond with traditional terminology which is therefore reviewed briefly below. Better general surveys of herbs used gynecologically in modern herbal therapeutics may be found in books by herbalists Amanda McQuade-Crawford and Ruth Trickey.

From the perspective of drug-herb interactions, herbs with identifiable hormone-like activities on the hypothalamic-pituitary-gonadal axis (HPA) are considered in Interactions™, although detailed studies and reports of interactions between pharmaceutical drugs and these agents are not available.
(Brinker F. Brit J Phytotherapy 1997;4,3:123-145; McQuade-Crawford A. 1997; Trickey R. 1998; Wilbur P. Eur J Herbal Med 1996 2.2:20-26, and 1996 2.3:19-26.)

food/herb group affecting drug performance: Oral Contraceptives

• mechanism: Phytoestrogenic constituents of foods and medicinal herbs may interact with steroid sex hormone metabolism, and synergize with exogenous steroid hormones in ERT (Estrogen Replacement Therapy), HRT (Hormone Replacement Therapy).

• herbal concerns: Despite lack of scientific evidence of adverse interactions, prudence suggests that herbs possessing direct endocrinological effects on the female reproductive tract should be avoided during treatment with ERT (Estrogen Replacement Therapy), HRT (Hormone Replacement Therapy), or GnRH (Gonadotrophic Releasing Hormone) inhibitors.

• herbal support: Cimicifuga racemosa (Black Cohosh) has been used to support withdrawal from HRT and ERT and to adjunctively treat symptoms of menopause.


herbs affecting Hypothalamic-Pituitary Axis (HPA):

• phytoestrogens: Phytoestrogens may be defined as plant constituents possessing the ability to mimic the biological effects of beta-estradiol in laboratory tests by their ability to bind to the nuclear estrogen receptor, activate transcriptional response and to promote growth of estrogen dependent MCF7 cells in culture. Phytoestrogenic activity is found among the following five naturally occurring chemical compound groupings which are widely distributed among medicinal and food plants:
• Isoflavonoids (e.g., formononetin, daidzein, genistein, coumestrol, biochanin A)
• Sterols (e.g., beta-sitosterol, stigmasterol)
• Saponins (e.g., diosgenin),
• Lignans (e.g., enterolactone),
• Essential oils (Clary sage, Fennel)
Isoflavonoid phytoestrogenic constituents are nutritionally available in plants from the Fabaceae (bean) family, particularly Glycine max (Soybean). Among medicinal plants, the most important phytoestrogenic plant in common therapeutic use is Cimicifuga racemosa (Black Cohosh).

Comprehensive lists of plants containing phytoestrogenic constituents can be found in various sources such as James Duke's Handbook of Phytochemical Constituents of GRAS Herbs and Other Economical Plants or the related database of the Agricultural Research Service - Phytochemical and Ethnobotanical Databases (http://www.ars-grin.gov/duke/) and the NAPRALERT database.
(Duke JA.1994; Miksicek R. Mol Pharmacol, 44(1):37-43, 1993.)

In clinical practice, it has long been known that phytoestrogenic medicinal herbs often have both estrogenic and anti-estrogenic actions. This variability in action remains to be elucidated in terms of potency of phytoestrogenic constituents, balance of agonistic and antagonistic tendencies and compounds, short and long term effects, as well as the problem of different methodological approaches used to identify estrogenicity. The functional endocrinological status of the consumer/patient adds to this complexity, although this is well understood by clinicians experienced in the use of these agents. For example, Cimicifuga racemosa (Black Cohosh) may be used to help correct estrogen dominance in pre-menopausal women yet supports estrogenic activity in post-menopausal women.

Herbalist David Hoffmann has recently reviewed developments in phytoestrogen research and considers that the FDA's National Center for Toxicological Research has identified the importance and need for further research in clarifying the roles of bioavailable estrogenic substances in three respects: estrogen agonism, estrogen antagonism, and endocrine disruption (particularly disruption of the development of secondary sexual characteristics and the reduction of sperm counts). The toxicology approach emphasizes the role of xenoestrogens rather then phytoestrogens, but nutritional phytoestrogens are included within the broad scope of future research and possible regulation. At present, only general conclusions can be made about the role of phytoestrogens which (after Hoffman D.) could be summarized:

1. A number of diverse plant constituents contribute significantly to human estrogen exposure at dietary levels.
2. Nutritionally available estrogenic substances can have a significant role in estrogen metabolism.
3. Biological activity of phytoestrogens extends beyond simple estrogen receptor activity to effects on cellular differentiation, proliferation, angiogenesis, enzyme inhibition, growth factor action and other effects which constitute protective activity against cancer.
4. Dietary incorporation of isoflavone rich foods may contribute to the reduction of risk of cancer; in particular, the majority of studies on soy isoflavones have confirmed significant anti-cancer effects.

aromatase modifiers: Some flavone and isoflavone constituents can inhibit aromatase. Aromatase is a P450 enzyme that catalyzes the formation of estrogens from androgens in many tissues. The activity is greater for flavone constituents rather than the isoflavone constituents, and while this may account for part of the anti-estrogenic activity of some flavonoid phytoestrogens, other herbs are known to reverse low aromatase activity, the most studied being Paeonia lactiflora (White peony). In vitro studies have shown the aromatase action of Paeonia to be due to the monoterpene glycoside, paeoniflorin.
(Chen S, et al. J Steroid Biochem Mol Biol 61,3-6:107-115,1997; Takeuchi T, et al. Am J Chin Med 1991;18:73-78.)

See also the following: Nutrients: Flavonoids, Quercitin and Grapefruit Juice

• direct pituitary agents: While Cimicifuga racemosa and soy products can influence pituitary action by peripheral modulation of LH and FSH via estrogenic effects, other herbs act directly upon the pituitary to modify prolactin, FSH and LH levels. The best known example is Vitex agnus-castus (Chasteberry). Animal studies have demonstrated Vitex inhibits prolactin levels in vitro and in vivo by binding to dopamine D2 receptors in the pituitary. Human studies have shown increase in progesterone levels in corpus luteum insufficiency during Vitex administration.

• oxytocics: Several plant constituents have been shown to have oxytocic activity, notably caulosaponin and caulophyllosaponin from Caulophyllum thalictroides (Blue Cohosh) which is classified as a traditional emmenagogue. Other oxytocic compounds include sparteine in Cytisus scoparius (Scotch Broom), and quinine from Cinchona species.

• commentary: Wild Yam and "Natural Progesterone": There has been some confusion concerning products containing Dioscorea villosa (Mexican Wild Yam) that claim to boost endogenous progesterone levels, or to be a form of "natural progesterone". To add to the confusion, some topical preparations actually contain both Dioscorea extract and pharmaceutical progesterone. The following points should be noted:
• The natural steroidal compound diosgenin is in fact estrogenic, not progesteronic.
• Diosgenin has been used as a starter compound in the laboratory synthesis of progesterone patented by Marker in the late 1940's known as the Marker Degradation Process.
• Homologous metabolic pathways do not exist humans, and diosgenin is therefore not a "precursor" for endogenous progesterone synthesis.
(Brinker F. Brit J Phytotherapy 1997;4,3:123-145; Wilbur P. Eur J Herbal Med 1996 2.2:20-26, and 1996 2.3:19-26.)

terminology: herbs directly affecting the uterus:
• Uterine Tonics: Herbs that re-establish normal tone of the uterine muscle and improve overall strength of the organ. Examples: Rubus idaeus (Red raspberry leaf), Angelica sinensis (Dong Quai), Chamaelerium luteum (Helonias, False Unicorn root).
• Uterine Spasmolytics: Herbs that reduce the rate and amplitude of uterine contractions. Examples: Viburnum opulus (Cramp bark), Viburnum prunifolium (Black Haw), Ligusticum wallichii (Chuang Xiong).
• Uterine Emmenagogues: Traditionally defined as herbs that accelerate delayed menses. More accurately, herbs that stimulate uterine contractions and hence may increase expulsive activity of the uterus.These have also been described as abortifacients. Examples: Ruta graveolens (Rue), Artemisia vulgaris (Mugwort), Mentha pulegium (Pennyroyal).
• Uterine Astringents: Herbs that have a vasoconstrictive action on the endometrial circulation. Examples: Achillea millefolium (Yarrow), Alchemilla vulgaris (Lady's mantle), Trillium erectum (Beth root), Capsella bursa-pastoris (Shepherd's Purse).



Herbs

Herbs listed in this section are compiled and edited from electronic databases including Professor Norman Farnsworth's NAPRALERT database at University of Chicago, Illinois, and Dr. James Duke's Phytochemical and Ethnobotanical Databases at the Agricultural Research Service. Textual sources include Michael Moore's Herbal/Medical Contraindications and Francis Brinker's Herb Contraindications and Drug Interactions.
(Moore M. 1995; Brinker F. 1998.)

Plant activities may be based upon widely different assay methods, and may be laboratory, in vitro, in vivo, or human studies. Constituent data is not quantified. Estrogenic constituents are very widely distributed and the following lists are limited to more common medicinal and edible plants. For principal herbs in common therapeutic gynecological use see Summary section of this Herb Group in Interactions™.

Herbs with HPA (Hypothalamic-Pituitary Axis) activty: Oxytocic synergists:
• Asclepias asperula (Immortal)
• Capsella bursa-pastoris (Shepherd's Purse)
• Cinchona spp. (Cinchona bark) *
• Claviceps purpurea (Ergot of Rye) *
• Cytisus scoparius (Scotch Broom)
• Gossypium spp.(Cotton root Bark)
• Leonurus cardiaca (Motherwort)
• Myristica fragrans (Nutmeg)
• Petroselinum crispum (Parsely)
• Senecio aureus (Life Root) *
• Stachys betonica (Wood Betony)

Herbs with HPA (Hypothalamic-Pituitary Axis) activity: Prolactin inhibitors:
• Glycyrrhiza glabra (Licorice root)
Paeonia lactiflora (Peony)
• Rehmannia glutinosa (Chinese Foxglove)
• Vitex agnus-castus (Chasteberry)
• Chinese herbal formula: Rehmannia Eight
• Chinese herbal formula: Paeonia and Glycyrrhiza

Herbs with HPA (Hypothalamic-Pituitary Axis) activity: FSH/LH modifiers:
• Cimicifuga racemosa (Black Cohosh)
• Tripterygium wilfordii (Lei Gong Teng) *
• Vitex agnus-castus (Chasteberry)

Herbs with HPA (Hypothalamic-Pituitary Axis) activity: Progestagenics:
• Alchemilla vulgaris (Ladie's mantle)
• Angelica sinensis (Dong Quai)
• Areca catechu (Betel nut)
• Ceanothus americanus (Red Root)
• Vitex agnus-castus (Chasteberry)

Chinese herbal formula: including:
• Angelica sinensis (Dong Quai)
• Astragalus membranaceus (Astragalus)
• Gardenia jasminoides (Zhi zi)
• Leonurus heterophyllus (Chinese Motherwort)
• Panax notoginseng (Pseudoginseng)
• Rubia cordifolia (Madder)
• Scutellaria baicalensis (Baical Skullcap)

Common phytoestrogenic food/herbs containing: Coumestrol
• Brassica spp. (Brussels Sprouts, Cabbage)
• Glycine max (Soybean)
• Medicago sativa (Alfalfa)
• Pisum sativum (Pea)
• Trifolium pratense (Red Clover)
• Vigna radiata (Mungbean)

Common phytoestrogenic food/herbs containing: Biochanin A:
• Baptisia tinctoria (Wild Indigo)
• Medicago sativa (Alfalfa)
• Sophora japonica (Japanese Pagoda Tree)
• Trifolium pratense (Red Clover)
• Vigna radiata (Mungbean)

Common phytoestrogenic food/herbs containing: Daidzein:
• Glycine max (Soybean)
• Phaseolus coccineus (Scarlet Runner Bean)
• Pueraria spp. (Kudzu; Pueraria)
• Trifolium pratense (Red Clover)
• Vigna radiata (Mungbean)

Common phytoestrogenic food/herbs containing: Formononetin:
• Astragalus membranaceus (Astragalus)
• Cimicifuga racemosa (Black Cohosh)
• Glycyrrhiza glabra (Licorice root)
• Medicago sativa (Alfalfa)
• Pueraria spp. (Kudzu; Pueraria)
• Trifolium pratense (Red Clover)
• Vigna radiata (Mungbean)

Common phytoestrogenic food/herbs containing: Genistein:
• Baptisia tinctoria (Wild Indigo)
• Cytisus scoparius (Scotch Broom)
• Glycine max (Soybean)
• Glycyrrhiza glabra (Licorice root)
• Medicago sativa (Alfalfa)
• Pueraria spp. (Kudzu; Pueraria)
• Sophora japonica (Japanese Pagoda Tree)
• Trifolium pratense (Red Clover)
• Vigna radiata (Mungbean)

Common phytoestrogenic food/herbs containing: Beta-Sitosterol:
• Achillea millefolium (Yarrow)
• Allium cepa (Onion)
• Allium sativum (Garlic)
• Aloe vera (Aloe)
• Anethum graveolens (Dill)
• Angelica archangelica (Angelica)
• Angelica sinensis (Dong Quai)
• Arctostaphylos uva-ursi (Bearberry)
• Arnica montana (Arnica)
• Artemisia annua (Sweet Annie)
• Artemisia dracunculus (Tarragon)
• Artemisia vulgaris (Mugwort)
• Asarum canadense (Wild Ginger)
• Asclepias syriaca (Milkweed)
• Aspidosperma quebracho-blanco (Quebracho)
• Astragalus membranaceus (Astragalus)
• Avena sativa (Oats)
• Calendula officinalis (Marigold)
• Capsella bursa-pastoris (Shepherd's Purse)
• Capsicum annuum (Chili Pepper)
• Centaurium erythraea (Centaury)
• Centella asiatica (Gotu Kola)
• Chimaphila umbellata (Pipsissewa)
• Cnicus benedictus (Blessed Thistle)
• Commiphora myrrha (Myrrh)
• Crataegus spp. (Hawthorn)
• Cucurbita pepo (Pumpkin)
• Cytisus scoparius (Scotch Broom)
• Daucus carota (Wild Carrot)
• Echinacea spp. (Echinacea)
• Elettaria cardamomum (Cardamom)
• Eleutherococcus senticosus (Siberian Ginseng)
• Equisetum arvense (Horsetail )
• Fagopyrum esculentum (Buckwheat)
• Foeniculum vulgare (Fennel)
• Fucus vesiculosus (Bladderwrack)
• Glycine max (Soybean)
• Glycyrrhiza glabra (Licorice root)
• Gossypium spp. (Cotton)
• Hordeum vulgare (Barley)
• Humulus lupulus (Hops)
• Hyssopus officinalis (Hyssop)
• Inula helenium (Elecampane)
• Lactuca virosa (Bitter Lettuce)
• Liquidambar orientalis (Oriental Styrax)
• Marrubium vulgare (Horehound)
• Medicago sativa (Alfalfa)
• Melilotus officinalis (Melilot)
• Melissa officinalis (Lemon Balm)
• Mentha spicata (Spearmint)
• Nicotiana tabacum (Tobacco)
• Ocimum basilicum (Basil)
• Oenothera biennis (Evening Primrose)
Paeonia lactiflora (Peony)
• Panax ginseng (Chinese Ginseng, Korean Ginseng)
• Panax quinquefolius (American Ginseng)
• Pisum sativum (Pea)
• Plantago psyllium (Psyllium seed)
• Ptychopetalum olacoides (Muira Puama)
• Punica granatum (Pomegranate)
• Rehmannia glutinosa (Chinese Foxglove)
• Rosmarinus officinalis (Rosemary)
• Salvia officinalis (Sage)
• Salvia sclarea (Clary Sage)
• Sambucus nigra (Elderflower)
• Sassafras albidum (Sassafras)
• Scutellaria baicalensis (Baikal Skullcap)
• Serenoa repens (Saw Palmetto)
• Smilax spp. (Sarsaparilla)
• Solanum dulcamara (Bitter Nightshade)
• Sophora japonica (Japanese Pagoda Tree)
• Taraxacum officinale ( Dandelion)
• Theobroma cacao (Cacao)
• Tribulus terrestris (Puncture-vine)
• Trifolium pratense (Red Clover)
• Trigonella foenum-graecum (Fenugreek)
• Turnera diffusa (Damiana)
• Urginea maritima (Squill)
• Valeriana officinalis (Valerian)
• Verbascum thapsus (Mullein)
• Viburnum opulus (Crampbark)
• Vinca minor (Periwinkle)
• Viola odorata (Sweet Violet)
• Vitis vinifera (Wine Grape)
• Withania somnifera (Ashwagandha)
• Zea mays (Corn silk)
• Zingiber officinale (Ginger)


(Missing are some NBE supplements)
Here's a few things about how testosterone works, if you look at the illustration below you'll see up 54% of testosterone get tied up in what's called Albumin, a protein in plasma that also carries hormones to receptor sites for growth. After coming across studies that states how inflammation can influence (down-regulate) how albumin is delivered you see that potential hormones are lost, (not activated). And once again, once you shut down the bio-availability of hormones they don't get activated, that includes high dose E in any form.

Remember-only hormones that detach from SHBG and Albumin are considered in the FREE state, about 2-5%, that's FREE testosterone and FREE estradiol, which will be available the bind with receptors and induce growth.

Solution- add omega 3's and 6's, at least a 1:1 ratio.

(07-03-2014, 03:15 PM)Lotus Wrote: [ -> ]The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.

Factors known to increase aromatase activity include age, obesity, insulin, gonadotropins, and alcohol. Aromatase activity is decreased by prolactin, anti-Müllerian hormone and the common herbicide glyphosate. Aromatase activity appears to be enhanced in certain estrogen-dependent local tissue next to breast tissue, endometrial cancer, endometriosis, and uterine fibroids.

Aromatase also converts androstenedione (a sex hormone precursor) to the female hormone estrone, another estrogen, although weaker than estradiol.


Aromatase
  • There's an enzyme in the bodies of both men and women called aromatase. Its primary action is to produce female sex hormones, or estrogens. It produces them from male sex hormones (androgens) such as testosterone and their precursors.
  • Aromatase also converts androstenedione (a sex hormone precursor) to the female hormone estrone, another estrogen, although weaker than estradiol.
  • If you increase the activity of aromatase, you can increase levels of female sex hormones (estradiol, estrone).
  • If you decrease the activity of aromatase, you can decrease levels of female sex hormones, while increasing relative levels of male sex hormones, e.g. testosterone.
  • Men's bodies normally contain some level of estrogens, in addition to testosterone and their kind. Likewise, women's bodies contain some level of male androgens including testosterone.
  • The ratio of male-to-female hormones contributes to our masculinity or femininity. Aromatase is one chemical that can tweak that ratio. It operates the same in both men and women, although an array of compounds can affect its activity.
__________________________


In men, testosterone is produced and secreted mainly by the testicles. Starting with cholesterol, testosterone is synthesized within the 500 million Leydig cells inside the testis. These specialized cells make up about 5% of the testis volume. A small amount of testosterone is made from DHEA in specialized areas of the body. This conversion accounts for a very small amount of your total testosterone.

Interestingly, giving a man DHEA at 50mg a day, will not increase his testosterone to acceptable replacement levels, but it will increase his estrogen level. However, a woman taking this dose, will see her testosterone increase.

The pituitary secretes luteinizing hormone (LH) in short bursts to signal the production and release of testosterone. The bursts occur every 60-90 minutes. Releasing LH in this manner maintains the Leydig cell’s sensitivity to LH and maintains the pattern of secretion. Constant stimulation and the Leydig cells will become resistant to the signal.

Men produce between 3mg and 10mg of testosterone per day with 4% being converted to dihydrotesterone (DHT) and about 0.2% being converted to estradiol, an estrogen.

DHT is 3 to 10 times as androgenic (male characteristics) as testosterone. The enzyme 5-alpha-reductase is responsible for this conversion of testosterone to DHT. In the prostate, 95% of testosterone is converted to DHT by 5-alpha-reductase. Specific medications can block this enzyme in the prostate. DHT, along with estrogen, is the contributing factor to an enlarged prostate. Testosterone has a protective benefit to the prostate.

A small percentage, just 0.2%, of testosterone is converted to estradiol by the enzyme aromatase. This may seem insignificant but estradiol is 100 times more potent at the cell receptor site than testosterone. This means that a male needs 100 times more testosterone than estradiol just to have an equal affinity for the receptor. Approximately 80% of estradiol in males is produced via this conversion from testosterone.

The major determining factor in the removal of testosterone from the body are SHBG levels, the individual’s circadian rhythm, amount of blood flow to the liver, genetics, and environmental factors. The clearance of testosterone from the body is reduced with lower SHBG levels and reduced blood flow to the liver.

Beginning around age 35, there is a gradual decrease in testosterone and increases in estrogen and SHBG. The decrease is accelerated and begins earlier with poor health or chronic illness.

Testosterone is transported by binding to SHBG. SHBG is made and secreted by the liver. SHBG binds 70% to 99% of the testosterone in a man’s body. The remaining 1% to 30% is either bound to other proteins or free to move into tissues resulting in an effect on the cell. The higher the SHBG concentration, the lower the amount of free testosterone available to the body. SHBG concentration is affected by testosterone levels, estrogen levels, liver disease, obesity, and genetics. Once bound to these proteins, the testosterone is rendered “inactive” and is taken to the liver for removal from the body.

Testosterone peaks for men in the early morning and slowly declines throughout the day with a low in mid-afternoon only to rise slightly again in the evening.

__________________________________


There is another enzyme that is also converted by aromatase called 5α-reductase, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer. There are three isoenzymes of 5-alpha reductase, which vary in different tissues with age.

5α-reductase inhibitors (5-ARIs) are a class of drugs with antiandrogen effects, used primarily in the treatment of benign prostatic hyperplasia (BPH) and androgenic alopecia.

These agents inhibit the enzyme 5α-reductase, which is involved in the metabolic transformations of a variety of endogenous steroids. 5α-reductase inhibition is most known for preventing conversion of testosterone, the major androgen sex hormone, to the more potent dihydrotestosterone (DHT), in androgen-associated disorders.

[Image: attachment.php?aid=7426]




Fantastic research . Thanks lotus Smile
Thanks MB,

You know what's interesting is that the needs of the +50 group in terms of AA's are different than of the +20's group. Both need aromatase, only the +50 group could use less anti-androgens because the lose of T over the years.

I can say with confidence that adding an omega 6 is a potent aromatase tool. I've been helping someone who is 20 something and since making a plan together he's seen significant growth in 3 weeks. I've also seen 1 inch growth in 3 weeks since tweaking with omega 3's and 6's.

(18-01-2015, 08:58 PM)Lotus Wrote: [ -> ]Thanks MB,

You know what's interesting is that the needs of the +50 group in terms of AA's are different than of the +20's group. Both need aromatase, only the +50 group could use less anti-androgens because the lose of T over the years.

I can say with confidence that adding an omega 6 is a potent aromatase tool. I've been helping someone who is 20 something and since making a plan together he's seen significant growth in 3 weeks. I've also seen 1 inch growth in 3 weeks since tweaking with omega 3's and 6's.

Lotus since I am a vege what would you suggest ?
(18-01-2015, 10:19 PM)myboobs Wrote: [ -> ]
(18-01-2015, 08:58 PM)Lotus Wrote: [ -> ]Thanks MB,

You know what's interesting is that the needs of the +50 group in terms of AA's are different than of the +20's group. Both need aromatase, only the +50 group could use less anti-androgens because the lose of T over the years.

I can say with confidence that adding an omega 6 is a potent aromatase tool. I've been helping someone who is 20 something and since making a plan together he's seen significant growth in 3 weeks. I've also seen 1 inch growth in 3 weeks since tweaking with omega 3's and 6's.

Lotus since I am a vege what would you suggest ?

Well you probably already know that saturated fats increases inflammation, how about walnuts?.

Do you drink tomato juice?, it's great for stimulating blood circulation.

The walnuts addresses a low inflammatory response and TJ for increased blood circulation towards improved bioavailability of albumin.
(18-01-2015, 11:11 PM)Lotus Wrote: [ -> ]
(18-01-2015, 10:19 PM)myboobs Wrote: [ -> ]
(18-01-2015, 08:58 PM)Lotus Wrote: [ -> ]Thanks MB,

You know what's interesting is that the needs of the +50 group in terms of AA's are different than of the +20's group. Both need aromatase, only the +50 group could use less anti-androgens because the lose of T over the years.

I can say with confidence that adding an omega 6 is a potent aromatase tool. I've been helping someone who is 20 something and since making a plan together he's seen significant growth in 3 weeks. I've also seen 1 inch growth in 3 weeks since tweaking with omega 3's and 6's.

Lotus since I am a vege what would you suggest ?

Well you probably already know that saturated fats increases inflammation, how about walnuts?.

Do you drink tomato juice?, it's great for stimulating blood circulation.

The walnuts addresses a low inflammatory response and TJ for increased blood circulation towards improved bioavailability of albumin.

Deviating away from the current topic and AFTER you have responded to mymoobs * waves hi to MM x "

Can you tell me does borage oil fit into "good omega 6" if you balanced out with omega 3?
I want to increase my omega 3 and 6 in a safe way. I've been told epo not good for estrogen Dom and wonder if borage oil also fits in that category...??

Am currently taking higher dose hemp oil which is 3/6 ratio but suspect fish oil is more productive for inflammation. . Huh



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