Breast Growth For Genetic Males

Full Version: Project X (hrt)
You're currently viewing a stripped down version of our content. View the full version with proper formatting.
Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482
(08-11-2014, 03:27 AM)ELLACRAIG Wrote: [ -> ]
(08-11-2014, 02:39 AM)pom19 Wrote: [ -> ]I just learned about Lotus leaving us, and it made me sad. I am not getting any notifications on my subscribed threads since Halloween!!! I checked the threads and they all say that I am set for immediate notifications. This even has happened to my own threads. Ella has posted couple posts om my thread "POM's Progress" on 11-2-14 and I did not get them until I was checking my threads and saw them on 11-4-14. Sorry Ella for responding so late. So strange. POM

Thats ok pom. It happened to me at one stage too. Yeh cant believe lotus has abandoned us Sad
-------------------------------------------------
He'll be back. Smile

F
T
Yup, I had read that same article, and others, including this one...

In the past three years, four papers or letters have been published purporting to demonstrate a link between the use of black cohosh ingestion and subsequent liver injury. The first publication was from Australia and described six patients with evidence of severe hepatitis linked to taking a range of herbal products.1 Two of these patients were taking black cohosh, although one also was taking other herbs, including skullcap, an herb that can be substituted by Teucrium species, a known hepatotoxic genus.2 The one case attributed to black cohosh alone (case 1) truly was dramatic. Of the cases reported, the most serious illness occurred in a 47-year-old woman taking black cohosh for menopausal symptoms. She required liver transplantation, even though, according to the publication, the patient had been taking the black cohosh for just one week. Histological examination of her liver confirmed severe hepatitis and early fibrosis. The patient did not exhibit eosinophilia and had no signs of any systemic disturbance. Serology for hepatitis A, B and C was negative, but rechallenge with the herb was not performed "for ethical reasons." The dose of black cohosh taken was not specified.

The second publication, also from Australia, described a 52-year-old woman with acute liver failure (case 2).3 She had been taking an herbal formula containing 1:1 liquid extracts prescribed by a pharmacist. Black cohosh 1:1 was 10 percent of the mixture and the daily dose of the combination was 7.5 mL twice a day. The patient underwent successful liver transplantation. Although the authors stated, "Extensive investigation excluded other recognized causes of liver failure," they provided no details of what these investigations were. Analysis was said to confirm the presence of golden seal, black cohosh and ginkgo in the herbal mixture. Other stated ingredients were ground ivy and oats seed.

The third and fourth publications detail single case reports from the U.S. One report described the development of autoimmune hepatitis, which the authors claim was triggered by the use of black cohosh (case 3).4 A 57-year-old diabetic woman presented with a two-week history of lethargy and fatigue. Her medications (all of which had been used for more than two years) included labetalol, fosinopril, verapamil, metformin, aspirin and insulin. Three weeks before presentation, the patient began taking black cohosh tablets (unknown brand or dose) for hot flashes. Drug-induced autoimmune hepatitis, attributed to the black cohosh, was diagnosed. Tests for hepatitis A, B and C were negative.

The most recent case report (case 4) was that of a 50-year-old woman suffering from acute-onset jaundice.5 The provisional diagnosis was autoimmune hepatitis, since tests for hepatitis A, B and C, cytomegalovirus and Epstein-Barr virus all were negative. In the five months prior to the onset of jaundice, the patient was taking black cohosh (500 mg daily) for menopausal symptoms and was not on any other medications.

The case reports linking black cohosh to liver injury have some serious flaws. In particular, for all cases, the presence of black cohosh in the products being consumed was not definitely established. Moreover, in most cases the name of the product and the dosage taken were not specified. Certainly for case 2, there is the assertion that black cohosh was identified in the herbal mixture, but no details of the results or how this was done are provided. The fact that two herbs in the mixture could not be identified makes any argument for the involvement of black cohosh in case 2 fundamentally flawed.

The features of case 1 are baffling. Since the problem developed after one week of taking black cohosh, this would have to be a hypersensitivity reaction if the herb truly was the cause. Yet the patient lacked any features of a hypersensitivity reaction (rash, fever, systemic reaction, eosinophilia). In fact, eosinophilia specifically was stated to be absent. Furthermore, the explant liver showed signs of early fibrosis, a phenomenon that could develop only after months of exposure to the causative agent. Clearly, on the evidence provided, one week of black cohosh is the least likely cause of this patient's liver damage.

For case 3, the authors claimed none of the drugs the patient was taking had been linked to autoimmune hepatitis. Yet a simple search revealed several cases for labetalol in which this drug might have indeed caused an idiosyncratic autoimmune hepatitis, including one overview report of 11 cases from the FDA.14,15,16

In case 4, the authors justify their identification of black cohosh as the cause of the patient's liver injury on the basis of the two flawed Australian publications. In their discussion, they attribute to black cohosh the presence of hepatotoxic alkaloids and salicylates. Such attributions are nonsensical, unsupported by the literature17 and, above all, cast doubt on the credibility and academic diligence of their overall analysis of the case.

Additional problems with the four cases include the lack of positive identification of black cohosh as the cause by either a rechallenge or a lymphocyte stimulation test. While the latter can give false negatives, if positive, it would have provided more conclusive evidence of any link to black cohosh use. But the likelihood is that most of the authors involved never actually saw what the patients were taking (as evidenced by the appalling lack of product and dosage information) and therefore would have been unable to undertake such tests.

The demographics of patients with non-A non-B (idiopathic) hepatitis closely match those of the black cohosh user (female, age 40-50). Hence, the most likely and rational explanation of the cases described is that they are idiopathic hepatitis mistakenly attributed to black cohosh because of the common use of this herb. Once one mistaken case is described in the literature - however poor its quality - others likely will follow in a process akin to a self-fulfilling prophecy. Hopefully, the regulators will not be motivated to act on such poor-quality case reports. The association of black cohosh and DILI remains unproven based on the current evidence.

F

[attachment=8307]
t


??i don't get it??




[Image: attachment.php?aid=8306]
[Image: attachment.php?aid=8307]


Put together "I get it", sorry dude, I like to put puzzles together.
(08-11-2014, 04:08 AM)pom19 Wrote: [ -> ]He'll be back. Smile

I truly hope so.....hope no more of you decide to take a sabbatical.
This is getting old!
Pom ....you stay right there! lol.

(08-11-2014, 01:48 PM)elainecd Wrote: [ -> ]
(08-11-2014, 04:08 AM)pom19 Wrote: [ -> ]He'll be back. Smile

I truly hope so.....hope no more of you decide to take a sabbatical.
This is getting old!
Pom ....you stay right there! lol.
==================================
Smile <3 POM

Hey there boobie growers,

Thank you for all the well wishes and pm's (truly moving). Soooo, after some reflection and a few cold one's lol, I realized I can't say goodbye just yet, apologies to anyone I offended, and tough luck to ones I didnt, lol. Big GrinRolleyes (what?, nothing but love) Wink
(10-11-2014, 02:17 AM)Lotus Wrote: [ -> ]Hey there boobie growers,

Thank you for all the well wishes and pm's (truly moving). Soooo, after some reflection and a few cold one's lol, I realized I can't say goodbye just yet, apologies to anyone I offended, and tough luck to ones I didnt, lol. Big GrinRolleyes (what?, nothing but love) Wink

I am extremely offended :p
Mind you 100 bucks would make forget all offence Wink Big Grin



NOOOOOOOOOOO YOU CAN'T LEAVE!! [Image: Teen-Wolf.gif]
Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482