[Lotus]

This is a great PDF study, for instance, phytoestrogens reduce aromatase, and only unbound estrogens can enter target-tissue cells and induce biological activity. Highlighted text are key points of interest.
_______________________

In women, estrogens are synthesized from cholesterol in the ovaries in response to pituitary hormones. In an adult woman with normal cycles, the ovarian follicle secretes 70 to 500 μg of estradiol per day, depending on the phase of the menstrual cycle. Estradiol can be converted to estrone and vice versa, and both can be converted to estriol, the major urinary metabolite. Estrogens are also produced by the aromatization of androgens in fat cells, skin, bone, and other tissues.

After menopause, most endogenous estrogen is produced in the peripheral tissues by the conversion of androstenedione, which is secreted by the adrenal cortex, to estrone. In addition, some estrogen continues to be manufactured by aromatase in body fat, and the ovaries continue to produce small amounts of the male hormone testosterone, which is converted to estradiol. The total estrogen produced after menopause, however, is far less than that produced during a woman’s reproductive years.

Nutritional Influences on Estrogen Metabolism
http://www.afmcp-sa.com/ansr/MET451%20En...20ANSR.pdf

[spanky]

I recently took note of warnings about 5 alpha reductase inhibitors possibly being associated with more aggressive prostate cancers.

http://www.drugs.com/fda/5-alpha-reducta...12977.html

Has there been further research to counter the warnings? I have been faithfully taking reishi for many months, but maybe there are risks that I should be taking into account.

[spanky]

A question I posted in the Anti-Androgens string that may be better here:

http://www.breastnexus.com/showthread.php?tid=17416&pid=148108#pid148108

[Lotus]

I recently took note of warnings about 5 alpha reductase inhibitors possibly being associated with more aggressive prostate cancers.

http://www.drugs.com/fda/5-alpha-reducta...12977.html

Has there been further research to counter the warnings? I have been faithfully taking reishi for many months, but maybe there are risks that I should be taking into account.

Hi Spanky, I did some checking, the main point would be to monitor your health with a PCP and get regular PSA screenings while on 5 ar therapy. There are other therapies discussed besides using 5 ar inhibitors, Reishi is an herbal remedy that's been used for a long time (ancient), and of course other herbals like SP, green tea, etc.

Questions and Answers: 5-alpha reductase inhibitors (5-ARIs) may increase the risk of a more serious form of prostate cancer

On June 9, 2011, the U.S. Food and Drug Administration (FDA) informed the public of new safety information for drugs called 5-alpha reductase inhibitors (5-ARIs). Men who take these drugs may have an increased risk of being diagnosed with a more serious form of prostate cancer (high-grade prostate cancer). The Warnings and Precautions section of the labels for all FDA-approved 5-ARIs have been revised to include information about this risk.
The following questions and answers address potential issues raised by this safety information.
Q1. What are 5-alpha reductase inhibitors (5-ARIs)?
Q2. What is high-grade prostate cancer?
Q3. Why have the labels of all 5-alpha reductase inhibitors (5-ARIs) been revised?
Q4. What data are available on this safety issue?
Q5. Why is the labeling of Propecia being changed when this drug was not included in either study?
Q6. Does FDA believe the benefits of 5-alpha reductase inhibitors (5-ARIs) still outweigh their risks for the approved indications?
Q7. What should men do if they are currently taking 5-alpha reductase inhibitors (5-ARIs)?
Q8. How should men taking 5-alpha reductase inhibitors (5-ARIs) be screened for prostate cancer?
Q9. Are there other medications to treat benign prostatic hyperplasia (BPH) or male pattern baldness?

http://www.fda.gov/Drugs/DrugSafety/ucm258358.htm



Hyperplasia Medications Do Not Increase Mortality In Men With Prostate Can

http://www.healthylivingmagazine.us/Articles/9107/

Dr. William D. Figg, from the National Cancer Institute, Bethesda, Maryland, and Dr. Ian M. Thompson, from the University of Texas Health Science Center at San Antonio, Texas wrote a commentary related to this report. Dr. Figg told Reuters Health by email, "These data should ease the concern of some urologists who have patients that need a 5-ARI, that it is safe to prescribe and that those patients are not at an increased risk of developing high-grade aggressive types of prostate cancer."

"I think the FDA should clearly re-evaluate the warning '5-alpha reductase inhibitor may increase the risk of a more serious form of prostate cancer' (Here: http://1.usa.gov/1yNWbgG), " Dr. Figg said.

Utility of 5-alpha-reductase inhibitors in active surveillance for favourable risk prostate cancer
http://www.ncbi.nlm.nih.gov/pmc/articles...12-450.pdf


American Urological Association Symptom Index - Topic Overview
http://www.webmd.com/urinary-incontinenc...c-overview

It's a interactive questionnaire that can help you determine how bad your urinary symptoms are and check how well your treatment is working.

________________________________

Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case–control study
http://www.ncbi.nlm.nih.gov/pmc/articles...e_9787.pdf

[spanky]

Thanks, Lotus. I appreciate the research.

The comments of Drs. Figg and Thompson are partuclarly encouraging. I used to get PSA tests done every year or two, but after all of the jawboning done in favor of "watchful waiting" rather than aggressive monitoring and treatment, I discovered that the my doctors is less favorably disposed to testing. Perhaps they are influenced by health care insurers who are less inclined to pay for testing if there is not a clear treatment path that the medical community agrees upon.

I think I will continue to take my reishi, drink my green tea, and cross my fingers.

[Lotus]

Thanks, Lotus. I appreciate the research.

The comments of Drs. Figg and Thompson are partuclarly encouraging. I used to get PSA tests done every year or two, but after all of the jawboning done in favor of "watchful waiting" rather than aggressive monitoring and treatment, I discovered that the my doctors is less favorably disposed to testing. Perhaps they are influenced by health care insurers who are less inclined to pay for testing if there is not a clear treatment path that the medical community agrees upon.

I think I will continue to take my reishi, drink my green tea, and cross my fingers.

Yup, I agree. And healthy humans don't turn a profit in the "for profit" money market..

[Roserose]

Lotus,

So E2 is crucial for NBE right? How do we increase E2 then?

[Lotus]

Lotus,

So E2 is crucial for NBE right? How do we increase E2 then?

Dfleurs,

I'd say it's essential, honestly there's no easy explaination on how to increase E2. Especially if you calculate age, pre and post menopause, bmi, health, pcos, etc. Take bmi as an example, it correlates more with E1 than E2, meaning E1 is displayed more in peripheral tissues, but increased BMI will lower SHBG production. On the other hand, flaxseed (lignan) will stimulate SHBG in liver, which reduces bioactive estrogen (free E2), down regulates aromatase, which as we know converts T into E.

What's troubling (IMO) is inhibiting the natural production of estrogens, phytoestrogens bind estrogen receptors, which is good in the way it prevents the proliferation of cancers, but what's replacing estrogens?, xenoestrogen? that (it) should be a concern. The point I'm making is I think natural estrogens, (despite all the bad press) coupled with some NBE anti-cancer supplementation is something worth looking into.

Sorry, you would think I'd have an easy explanation/solution, but, if you asked your question in the genetic male section lol........the explanation would be a lot easier .......obviously.

Great question though, btw, I've already provided the answer several times over throughout this thread. Come to think of it?, dozens of threads, lmao. But......."you" cool to me, so I'll answer with some new perspectives.

Thanks,

[Roserose]

So sorry lotus for making you keep on repeating the same thing, i am totally a noob when coming to [/align] scientific stuff so i might have overlooked it in the thread

But thanks a lot for explaining and answering it again. I have just added reishi in my program, hope it will works for me

[Lotus]

So sorry lotus for making you keep on repeating the same thing, i am totally a noob when coming to [/align] scientific stuff so i might have overlooked it in the thread

But thanks a lot for explaining and answering it again. I have just added reishi in my program, hope it will works for me

No apologies necessary , honestly the tech stuff doesn't come with a manual that we all can understand, too bad huh?.

Ask away, if anything sharing info helps us to better our programs. For instance E1, (estrone) is derived from peripheral aromatization of androstenedione (mainly adrenal)".

E2 is produced primarily in ovaries and testes by aromatization of testosterone. Small amounts are produced in the adrenal glands and some peripheral tissues, most notably fat. By contrast, most of the circulating E1 is derived from peripheral aromatization of androstenedione (mainly adrenal). E2 and E1 can be converted into each other, and both can be inactivated via hydroxylation and conjugation. E2 demonstrates 1.25-5 times the biological potency of E1. E2 circulates at 1.5-4 times the concentration of E1 in premenopausal, nonpregnant women.