[vidhushi]

Hi,
Wouldn't it be safer to take PM liquid extract through sublingual method? It would avoid the 1st liver pass.

[BonitaDDs]

You could try it if its pm liquid for internal use like if its a liquid that is to put with lotion or massage it would probably not be suitable because it could contain other ingredients for that purpose not good to go in your mouth
But Yh you could always try putting it under your tongue a while before you swallow then you'd get the best of both methods.

[MyNewGyrlz]

You can use the PM extract from Ainterol for that, that is what I do.

[Lenneth]

You can use the PM extract from Ainterol for that, that is what I do.

how well is it working for you?

[vidhushi]

In fact I've just started taking the Ainterol extract too.

The taste is not very nice though.

[chrishoney]

From my understanding this is completely unnecessary with PM and possibly even counterproductive.

Unnecessary because PM does not have the same kinds of health risks as oral conjugated estrogens. Sublingual administration of conjugated estrogens is thought to give them more time in general circulation (and thus have more feminizing effects) by avoiding the hepatic portal vein system and the dreaded "first pass."

With drugs like Premarin (which contains the weakest of the three types of estrogen in humans), high oral doses were necessary because it was so weak and so much was metabolized/broken down by the liver before entering general circulation, since blood from the intestines goes directly to the liver before going to the rest of the body. For food, this aids digestion and absorption, but a large percentage of the estrones in Premarin were rendered ineffective immediately by the liver. Higher doses made sure more got into general circulation, but higher doses also had WAY more health risks. PM does not have the same level of health risks so it is not necessary to avoid the first pass to try to reduce dosage levels while maintaining adequate feminizing effects.

Avoiding the "first pass" through the liver is probably counterproductive because PM contains numerous estrogenic substances, at least one of which is metabolized into a more potent form by, you guessed it, the liver! (see this study which suggests PM needs to be metabolically activated to have maximum estrogenic effects; http://www.sigmapharma.net/references/J_...rifica.pdf and this study confirming metabolic activation necessary for estrogenic effect: http://www.sciencedirect.com/science/art...2208000303)

The liver is the primary site for metabolizing drugs/food/substances in the blood. Therefore, by avoiding the liver you do not get the maximum estrogenic effect from PM since the metabolic activation referred to above, is delayed. Other studies have suggested this enzymatic process seems aided by the presence of dairy products, possibly the calcium they contain.

Hope this helps.

[vidhushi]

Thank you so much for these clarifications.