31-12-2019, 10:34 PM
So I had significant growth while taking 1650-3300 mg of pm capsules and 3 mg licorice extract.
Do not do this!!! You are putting yourself at risk of blood clotting, stroke, etc.
I'm not taking any supplements now but am researching topical options now, anything to bypass the liver on the first pass.
I have started using the Swiss Botany PM serum these past 4 weeks. My nipples are sensitive and my nipples are constantly poking out again. It's good to have this feeling again with much less risk.
Right now I'm having trouble finding the extract ratio of PM serum compared to capsule powder.
I'm also having difficulty figuring out how much miroestrol, deoxymiroestol, and puerarin is in the serum.
I've seen discussions but nothing authoritative that 500 mg of PM powder is equivalent to 0.16 mg of estradiol. This seems too high but maybe not.
I've heard of mtf folks taking 2-8 mg estradiol for transitioning and that about 5% of the estrogen even makes it to the bloodstream before the liver gets it. That means they are getting 0.1-0.4 mg of estradiol daily in their bloodstream.
Seems suspicious that 500 mg of PM equals 0.16 mg. Perhaps they meant 0.16 mcg (micrograms). Or if it is 0.16 mg, this would still be 12.5 times less than the lowest dose of estradiol for transitioning (2mg). So 6,250 mg PM would be equivalent to 2mg of estradiol.
If 500 mg of PM is equivalent to 0.16mg of estradiol then at my 3300 mg dose I was getting 1.056 mg estradiol equivalent. If this is true I think I would have to take 13,200 mg (13.2 grams) daily to match mtf estradiol dose of 4mg daily.
There has got to be a better topical option.
I'm very curious how much miroestrol can pass through the skin to the bloodstream.
I see that with regards to estradiol the dose equivalent of 1mg oral is 0.05 mg transdermal. In other, words you need 1/20 less for similar effect.
I wonder if PM serum might be 20 times more potent when absorbed through the skin versus taken orally.
Assuming 500 mg of dried PM equals 0.16 mg equivalent of estradiol and that the equivalent amount of serum is absorbed through the skin at a rate of 5%, 10%, 25%, or 50% then in order to reach a minimal mtf dose equivalent of 2mg oral estradiol then you would need 6250 mg (5%), 3125 mg (10%), 1250mg (25%), 625 mg (50%) of PM serum.
So the trick is to find out what the extraction ratio from raw PM powder to serum is AND what the absorption rate is for Miroestrol and Deoxymiroestrol.
Do not do this!!! You are putting yourself at risk of blood clotting, stroke, etc.
I'm not taking any supplements now but am researching topical options now, anything to bypass the liver on the first pass.
I have started using the Swiss Botany PM serum these past 4 weeks. My nipples are sensitive and my nipples are constantly poking out again. It's good to have this feeling again with much less risk.
Right now I'm having trouble finding the extract ratio of PM serum compared to capsule powder.
I'm also having difficulty figuring out how much miroestrol, deoxymiroestol, and puerarin is in the serum.
I've seen discussions but nothing authoritative that 500 mg of PM powder is equivalent to 0.16 mg of estradiol. This seems too high but maybe not.
I've heard of mtf folks taking 2-8 mg estradiol for transitioning and that about 5% of the estrogen even makes it to the bloodstream before the liver gets it. That means they are getting 0.1-0.4 mg of estradiol daily in their bloodstream.
Seems suspicious that 500 mg of PM equals 0.16 mg. Perhaps they meant 0.16 mcg (micrograms). Or if it is 0.16 mg, this would still be 12.5 times less than the lowest dose of estradiol for transitioning (2mg). So 6,250 mg PM would be equivalent to 2mg of estradiol.
If 500 mg of PM is equivalent to 0.16mg of estradiol then at my 3300 mg dose I was getting 1.056 mg estradiol equivalent. If this is true I think I would have to take 13,200 mg (13.2 grams) daily to match mtf estradiol dose of 4mg daily.
There has got to be a better topical option.
I'm very curious how much miroestrol can pass through the skin to the bloodstream.
I see that with regards to estradiol the dose equivalent of 1mg oral is 0.05 mg transdermal. In other, words you need 1/20 less for similar effect.
I wonder if PM serum might be 20 times more potent when absorbed through the skin versus taken orally.
Assuming 500 mg of dried PM equals 0.16 mg equivalent of estradiol and that the equivalent amount of serum is absorbed through the skin at a rate of 5%, 10%, 25%, or 50% then in order to reach a minimal mtf dose equivalent of 2mg oral estradiol then you would need 6250 mg (5%), 3125 mg (10%), 1250mg (25%), 625 mg (50%) of PM serum.
So the trick is to find out what the extraction ratio from raw PM powder to serum is AND what the absorption rate is for Miroestrol and Deoxymiroestrol.