Multiple study's point out that certain hormones need to be present (at the same time) to induce breast growth. My conclusion (based on research studies and my own personal results) listed below discusses the missing parts of NBE/HRT. (Choose 1 from each, except EGF (epidermal growth factor) is 2 from that group.
GH-growth hormone
-HOPS (8-PIN) stimulates IGF-1,........growth hormone stimulates IGF-1 (insulin growth factor). This action stimulates new growth. Exercise & sleep, whey (denatured), cayenne pepper stimulates IGF-1 and circulation (inhibits androgens in the prostate). Vitamin D stimulates IGF-1
PRL-prolactin
-hops, milk thistle, nipple stimulation
PR-progesterone & progestrone receptor
-red clover and a structurally similar flavonoid, apigenin, bound to PR and induced progestegenic activity and P4 regulated genes in breast epithelial cells and human endometrial stromal cells (HESC). Kaempferol and apigenin demonstrated higher progestegenic potency in the HESC compared to breast epithelial cells
E2-estradiol-
fenugreek, Hops (binds to breast receptor A), authentic PM. adipose tissue (fat) contributes up to 100% of circulating estrogen in postmenopausal women. I see older genetic males somewhere close to postmenopausal women, BMI being a factor.
EGF- epidermal growth factor-
linoleic acid (18:2 omega 6) and prostaglandin E2 or cAMP has synergistic effect on EGF-stimulated growth (stimulates mammary epithelial cells).
My choice is EPO (evening primrose oil- plus krill oil)....though peanut oil and borage oil could work too. I'll do EPO 2x daily, 1 krill oil per day, then peanuts (high in biotin) with EPO later.
Anti-Androgens and aromatase are still needed, but I see these added at specific times. Meaning taking anti-androgens and aromatase together, then followed by E2/phytoestrogens.
(However, EGF stimulates aromatase..........and EPO inhibits DHT and promotes aromatase). In other words, it's mainly that omega 6's and PGE2 targets these actions.
As we know anti-androgens inhibit 5 alpha reductase, then aromatase converts it to estrogens.
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Personally, I've added some items to my HRT program to address the multiple hormone approach and have seen a 1/2 growth in the past 3 weeks, 2 inches total since May. Granted, my situation is different from others, I'm not saying you'll see similar results, but it's encouraging based on doing this for the past 4 years. The items I've added are supplements.
E2 4mg x2 daily
Spiro 100mg x2 daily
EPO (evening primrose oil) 1000mg x2 daily
Krill oil 500mg x1 daily
Gelatin 1300mg x2 daily
Vitamin C 500 mg 1x daily
Biotin 5000mcg x2 daily
Magnesium 250mg X1 daily
Calcium 600mg x2 daily
Water 8+ cups daily (w/lemon wedge)
Green Tea 3 cups
I've covered enough of the science in past posts which highlights this info, feel free to read. One other thing I've found very helpful is a tube bra.....lol true. I think it helps move (or keep) breast fat moving forward. The ability to reposition it right below the underarms moves that annoying extra spillage you see overflowing from bras. There's one size fits all or larger ones available, the bands do get uncomfortable after awhile, shop around though. The flush of breast fats/blood moving forward also increases areola sensitivity.
Other moving parts to all this obviously still needs addressing, (exercise/sleep are two such examples that need further mention). A quick note though is coordinating exercise via the release of hormones and supplement timing, (imo, exercise within 1 hour) whether that's 20 squats, walking, HIIT (high intensity interval training), breast isometrics is up to you.